Evidence map›Paper›PMID 34216301›Full record

ReviewThe Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology2021

Association of Helicobacter pylori infection with coronary artery disease: is it an independent risk factor?

Mohamed Riad

Open access · diamondAbstract readReview
In one paragraph

Review in The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Interpretable machine learning analysis for relationships betweenFrontiers in cellular and infection microbiology · 2026
    Article
  3. Glucolipid Metabolic Disorders andInternational journal of endocrinology · 2026
    Review
  4. Article
  5. Metabolism open · 2025
    Review
  6. Article
  7. Article
  8. Relationship betweenWorld journal of gastrointestinal surgery · 2024
    Article
  9. The Role ofJournal of clinical medicine · 2024
    Review
  10. Impact ofFrontiers in gastroenterology (Lausanne, Switzerland) · 2024
    Review
  11. Article
  12. Infection withFrontiers in pharmacology · 2023
    Review
  13. Journal of clinical medicine · 2022
    Review
  14. Vitamin D3 is well Correlated with Anti-Advanced biomedical research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mohamed RiadMansoura University Faculty of Medicine, Elgomhouria street, Mansoura city, Dakahlia, Egypt. mohamed.riad22@yahoo.com.ORCID http://orcid.org/0000-0002-4476-5895
Mansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary artery disease (CAD) is a dilemma and a serious cause of morbidity and mortality worldwide. Since CAD has been seen in people without the conventional risk factors like smoking, diabetes, and hypertension, the infectious theory being a risk factor has arisen. MAIN BODY: Helicobacter pylori (HP) infection is the most common infection affecting the vast majority of the population worldwide. HP grows in the gastrointestinal tract (GIT) and responsible for chronic gastritis, peptic ulcer, gastric adenocarcinoma, and gastric lymphoma. A review of medical literature mainly PubMed has revealed several studies reporting that HP pathogenesis extends beyond the GIT to be a predisposing factor for atherosclerosis, dyslipidemia, thrombosis, and CAD. However, it remains a controversial issue that warrants extensive research.

conclusionThis article gives insight into the diversity of opinions, evidence, and theories regarding the association between HP infection and CAD. The idea that CAD may be managed with antibiotics in certain patients seems to be creative and inspiring. More research is mandatory to either verify or reject this proposed correlation with strong scientific evidence and also to demonstrate the implications of the results on CAD management and outcome.

Indexed as

AtherosclerosisCoronary artery diseaseDyslipidemiaHelicobacter pyloriInfectionStrokeThrombosis

Identifiers

PMID34216301
PMCPMC8254686
OpenAlexW3175256127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.