ArticleClinical and experimental nephrology2021
The distribution of eGFR by age in a community-based healthy population: the Japan specific health checkups study (J-SHC study).
Article in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Pooled it
- Sex Differences in 6-Year Change in eGFR and ACR in a Multiethnic Population: The HELIUS Study.Kidney medicine · 2026Article
- Sex-specific associations between annual kidney function changes and weight/waist changes in overweight Japanese: Japan Specific Health Checkup cohort.Endocrine journal · 2026Article
- Development and Validation of a Nomogram for Predicting Acute Kidney Injury in Acute Respiratory Distress Syndrome.Journal of inflammation research · 2026Article
- The aging-related GFR decline in Chinese healthy elderly.International urology and nephrology · 2026Article
- Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study.Scientific reports · 2024Article
- The association between the estimated glomerular filtration rate and cognitive impairment: the Suita Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Healthy Lifestyle and Incident Hypertension and Diabetes in Participants with and without Chronic Kidney Disease: The Japan Specific Health Checkups (J-SHC) Study.Internal medicine (Tokyo, Japan) · 2022Article
- Evaluation of the Effect of Topiroxostat on Renal Function in Patients with Hyperuricemia: STOP-C Study, a Retrospective Observational Cohort Study.Drugs - real world outcomes · 2022Article
- Renal Function Following Bariatric Surgery: a Literature Review of Potential Mechanisms.Obesity surgery · 2022Review
- Changes in Prevalence and Health Checkup Coverage Rate of Chronic Kidney Disease (CKD) after Introduction of Prefecture-Wide CKD Initiative: Results of the Kagawa Association of CKD Initiatives.Journal of personalized medicine · 2021Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRenal function gradually declines with age. However, the association between changes in renal function and healthy aging has not been determined. This study examined the distribution of estimated glomerular filtration rate (eGFR) values in healthy subjects by age using large-scale cross-sectional data of health check-up participants in Japan.
methodsAmong the 394,180 health check-up participants, 75,217 (19.1%) subjects without hypertension, diabetes, hyperlipidemia, obesity, proteinuria, smoking, past history of cardiovascular diseases, and renal failure/not undergoing dialysis were included in the healthy group. The distribution of eGFR values was determined at each age between 39 and 74 years.
resultsin healthy subjects, the mean (± 2 SD range) values of eGFR (mL/min/1.73 m
conclusionsRenal function slowly declined with age in a healthy population; however, it was relatively preserved until the mid 70 s. This result suggests that a decline in renal function often observed in the elderly does not attribute to aging alone, and further examination might be required to clarify the cause of renal impairment.
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