Evidence map›Paper›PMID 34216265›Full record

Trial reportEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Clinical features in maxillary sinus fungus ball in patients with malignant hematological disease.

Yang Yang, Zhimin Xing, Lisheng Yu, Xiaopei Yuan, Min Wang, Congli Geng, Yan Liu, Shichang Li, Yuanjun Liu

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Maxillary sinus marginal calcification: A novel radiological entity distinct from maxillary sinus fungal ball.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yang YangDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Zhimin Xing *Department of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China. xing_zhimin27@163.com.ORCID http://orcid.org/0000-0002-4325-9392
Lisheng Yu *Department of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Xiaopei YuanDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Min WangDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Congli GengDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Yan LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Shichang LiDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Yuanjun LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Peking University · CN

Funding

Natural Science Foundation of Beijing Municipality 7202215
6 · The paper itself

Abstract

purposePrevious studies on fungus balls have primarily focused on immunocompetent patients, and only a few studies have described the clinical characteristics of fungus balls in malignant hematological disease (MHD) patients. Therefore, we compared the clinical features of maxillary sinus fungus ball (MSFB) between immunosuppressive patients with MHD and immunocompetent patients.

methodsTwenty patients with MHD and 40 randomly selected immunocompetent patients were enrolled and divided into MHD and non-MHD groups. All patients were diagnosed with MSFB and their clinical features were retrospectively analyzed.

resultsPatients in the MHD group had non-specific clinical symptoms and endoscopic manifestations of MSFB, similar to those in the non-MHD group. On computed tomography (CT), the MHD group showed higher Lund-Mackay scores, lesser single sinus opacifications, more multiple sinus opacifications on the affected side, and more bilateral opacifications compared to the non-MHD group. The MHD group had a lower frequency of central hyper-density and heterogeneous opacifications than the non-MHD group. There were no significant differences between the two groups in terms of the fungal-infected side, lateral sinus wall ratio, sclerosis of the lateral sinus wall, erosion of the inner sinus wall, and nasal septum deviation.

conclusionThe clinical symptoms and endoscopic manifestations of MSFB in patients with MHD were similar to those of immunocompetent patients. However, more atypical signs and wider mucosal inflammation were found on CT scans of MSFB patients with MHD. These results indicate that caution should be executed when excluding the possibility of fungus balls in immunosuppressive patients.

Indexed as

Foreign BodiesHematologic DiseasesFungiHumansMaxillary SinusRetrospective StudiesClinical characteristicsImmunosuppressive patientsMalignant hematological diseaseMaxillary sinus fungus Ball

Identifiers

PMID34216265
OpenAlexW3175387853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.