Evidence map›Paper›PMID 34216258›Full record

ArticleArchives of orthopaedic and trauma surgery2022

Soaking ACL grafts in vancomycin solution (1 mg/ml) reduces the infection rate without increasing the risk for re-rupture and arthrofibrosis.

Tilman Hees, Yassen Abdelatif, Katrin Karpinski, Sebastian Bierke, Martin Häner, Hi Un Park, Wolf Petersen

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Article in Archives of orthopaedic and trauma surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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  12. A fast, easy and reliable method for hamstrings graft size prediction in anterior cruciate ligament reconstruction.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tilman HeesKlinik Für Orthopädie Und Unfallchirurgie, Martin Luther Krankenhaus, Grunewald Caspar Theyss Strasse 27-31, 14193, Berlin, Germany.ORCID http://orcid.org/0000-0003-0112-9407
Yassen AbdelatifKlinik Für Orthopädie Und Unfallchirurgie, Martin Luther Krankenhaus, Grunewald Caspar Theyss Strasse 27-31, 14193, Berlin, Germany.
Katrin KarpinskiKlinik Für Orthopädie Und Unfallchirurgie, Martin Luther Krankenhaus, Grunewald Caspar Theyss Strasse 27-31, 14193, Berlin, Germany.
Sebastian BierkeKlinik Für Orthopädie Und Unfallchirurgie, Martin Luther Krankenhaus, Grunewald Caspar Theyss Strasse 27-31, 14193, Berlin, Germany.
Martin HänerKlinik Für Orthopädie Und Unfallchirurgie, Martin Luther Krankenhaus, Grunewald Caspar Theyss Strasse 27-31, 14193, Berlin, Germany.
Hi Un ParkKlinik Für Orthopädie Und Unfallchirurgie, Martin Luther Krankenhaus, Grunewald Caspar Theyss Strasse 27-31, 14193, Berlin, Germany.
Wolf PetersenKlinik Für Orthopädie Und Unfallchirurgie, Martin Luther Krankenhaus, Grunewald Caspar Theyss Strasse 27-31, 14193, Berlin, Germany. wolf.petersen@jsd.de.
Martin-Luther-Krankenhaus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the present study was to evaluate if the vancomycin (1 mg/ml) is effective for the prevention of septic arthritis after ACL reconstruction. The hypothesis was that local antibiotic prophylaxis by soaking ACL grafts in vancomycin results in significantly less infections than ACL reconstruction without local antibiosis.

methodsIn group 1, 636 patients who were operated between 1.9.2014 and 31.8.2016 received no local antibiotic treatment with vancomycin. In group 2, 536 patients who were operated between 1.9.2016 and 31.8.2018 received local antibiotic treatment with vancomycin (1 mg/ml). In this group the graft was soaked in the vancomycin solution for 10 min prior to graft passage and fixation.

resultsIn group 1 (ACL reconstruction without vancomycin application), a postoperative infection was detected in ten patients (infection rate: 1.6%). In group 2 (ACL reconstruction with 1 mg/ml vancomycin), no postoperative infection was detected (infection rate: 0%). The statistical analysis showed a clear significant difference between the two groups (p = 0.002). The re-rupture rate and the rate of arthrofibrosis differed not significantly between the two treatment groups (p = 0.526).

conclusionThe results of the present study show that graft soaking in vancomycin (1 mg/ml) is effective for the prevention of septic arthritis after ACL reconstruction. LEVEL OF EVIDENCE: III.

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionArthritis, InfectiousJoint DiseasesAnti-Bacterial AgentsHumansPostoperative ComplicationsVancomycinAnti-Bacterial AgentsVancomycinACL reconstructionAntibiosisAntibiotic prophylaxisGraft failureInfection staphylococcusKnee infectionSeptic arthritis

Identifiers

PMID34216258
OpenAlexW3174801302

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.