Evidence map›Paper›PMID 34216242›Full record

ArticleWorld journal of urology2021

Multicenter external validation of the radical cystectomy pentafecta in a European cohort of patients undergoing robot-assisted radical cystectomy with intracorporeal urinary diversion for bladder cancer.

P Baron, Z Khene, F Lannes, G Pignot, A S Bajeot, G Ploussard, G Verhoest, A Gasmi, O Perrot, M Roumiguie and 5 more

Abstract readMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

P BaronDepartment of Urology, University Hospital of Tours, Loire Valley, Tours, France.
Z KheneDepartment of Urology, Rennes University Hospital, Rennes, France.
F LannesService de Chirurgie Oncologique 2, Institut Paoli-Calmettes, Marseille, France.
G PignotService de Chirurgie Oncologique 2, Institut Paoli-Calmettes, Marseille, France.
A S BajeotDepartment of Urology, Andrology and Renal Transplantation, CHU Rangueil, Toulouse, France.
G PloussardDepartment of Urology, Clinique La Croix du Sud, Toulouse, France.
G VerhoestDepartment of Urology, Rennes University Hospital, Rennes, France.
A GasmiDepartment of Urology, Rennes University Hospital, Rennes, France.
O PerrotDepartment of Urology, Sorbonne Université, GRC no 5, predictive onco-urology, AP-HP, Hôpital Pitié-Salpêtrière, Urology, 75013, Paris, France.
M RoumiguieDepartment of Urology, Andrology and Renal Transplantation, CHU Rangueil, Toulouse, France.
K MoriDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
G E CacciamaniUSC Institute of Urology, University of Southern California, Los Angeles, CA, USA.
M RouprêtDepartment of Urology, Sorbonne Université, GRC no 5, predictive onco-urology, AP-HP, Hôpital Pitié-Salpêtrière, Urology, 75013, Paris, France.
F BruyèreDepartment of Urology, University Hospital of Tours, Loire Valley, Tours, France.
B PradereDepartment of Urology, University Hospital of Tours, Loire Valley, Tours, France. benjaminpradere@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo perform an external validation of this RC-pentafecta.

methodBetween January 2014 and December 2019, 104 consecutive patients who underwent RARC with ICUD within 6 urological centers were analyzed retrospectively. Patients who simultaneously demonstrated negative soft tissue surgical margins (STSMs), a lymph node (LN) yield ≥ 16, absence of major (Clavien-Dindo grade III-V) 90-day postoperative complications, absence of UD-related long-term sequelae, and absence of 12-month clinical recurrence were considered to have achieved RC-pentafecta. A multivariable logistic regression model was used to measure predictors for achieving RC-pentafecta. We analyzed the influence of this RC-pentafecta on survival, and the impact ofthe surgical experience.

resultsSince 2014, 104 patients who had completed at least 12 months of follow-up were included. Over a mean follow-up of 18 months, a LN yield ≥ 16, negative STSMs, absence of major complications at 90 days, and absence of UD-related surgical sequelae and clinical recurrence at ≤ 12 months were observed in 56%, 96%, 85%, 81%, and 91% of patients, respectively, resulting in a RC-pentafecta rate of 39.4%. Multivariate analysis showed that age was an independent predictor of pentafecta achievement (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.90. 0.99; p = 0.04). The surgeon experience had an impact on the validation of the criteria.

conclusionThis study confirmed that the RC-pentafecta is reproducible and could be externally used for the outcome assessment after RARC with ICUD. Therefore, the RC-pentafecta could be a useful tool to assess surgical success and its impact on different outcomes.

Indexed as

Robotic Surgical ProceduresAgedCystectomyEuropeFemaleHumansMaleMiddle AgedRetrospective StudiesUrinary Bladder NeoplasmsUrinary DiversionBladder neoplasCystectomyRoboticsUrinary diversionUrothelial carcinomaValidation

Identifiers

PMID34216242
PMCPMC8602171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.