Evidence map›Paper›PMID 34216206›Full record

ArticleJournal of Crohn's & colitis2021

Nutrient, Fibre, and FODMAP Intakes and Food-related Quality of Life in Patients with Inflammatory Bowel Disease, and Their Relationship with Gastrointestinal Symptoms of Differing Aetiologies.

Selina R Cox, Hazel Clarke, Majella O'Keeffe, Patrick Dubois, Peter M Irving, James O Lindsay, Kevin Whelan

Open access · hybridAbstract read
In one paragraph

Article in Journal of Crohn's & colitis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Effects of a Low FODMAP Diet in Inflammatory Bowel Disease and Patient Experiences: A Mixed Methods Systematic Literature Review and Meta-Analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
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  10. Dietary and physical activity habits of adults with inflammatory bowel disease in Aotearoa, New Zealand: A cross-sectional study.Nutrition & dietetics : the journal of the Dietitians Association of Australia · 2025
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  20. British Dietetic Association consensus guidelines on the nutritional assessment and dietary management of patients with inflammatory bowel disease.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Selina R CoxKing's College London, Faculty of Life Sciences and Medicine, Department of Nutritional Sciences, London, UK.
Hazel ClarkeKing's College London, Faculty of Life Sciences and Medicine, Department of Nutritional Sciences, London, UK.
Majella O'KeeffeKing's College London, Faculty of Life Sciences and Medicine, Department of Nutritional Sciences, London, UK.
Patrick DuboisKing's College Hospital NHS Foundation Trust, Department of Gastroenterology, London, UK.
Peter M IrvingGuy's and St Thomas' NHS Foundation Trust, Department of Gastroenterology, London, UK.
James O LindsayBarts Health NHS Trust, Department of Gastroenterology, Royal London Hospital , London, UK.
Kevin WhelanKing's College London, Faculty of Life Sciences and Medicine, Department of Nutritional Sciences, London, UK.ORCID 0000-0001-5414-2950
King's College London · GBBarts Health NHS Trust · GBGuy's and St Thomas' NHS Foundation Trust · GBKing's College Hospital NHS Foundation Trust · GB

Funding

Kenneth Rainin Foundation
6 · The paper itself

Abstract

BACKGROUND AND

aimsCertain foods are reported as gut symptom triggers in inflammatory bowel disease [IBD], and fructans are shown to worsen non-inflammatory symptoms in inactive IBD, which may result in self-imposed dietary restrictions. The aim of this study was to investigate nutrient and FODMAP intakes, and the relationship between gut symptoms and dietary intake, in IBD.

methodsNutrient, fibre, and FODMAP intakes were estimated using 7-day food records in patients with active IBD [Active IBD], inactive IBD with non-inflammatory gut symptoms [Inactive IBD-GI], inactive IBD without gut symptoms [Inactive IBD], and healthy controls. Nutrient intakes, numbers of participants achieving national recommendations, and food-related quality of life [FR-QoL] were compared across study groups.

resultsFood diaries were obtained from 232 patients with IBD [65 Active IBD, 86 Inactive IBD-GI, 81 Inactive IBD] and 84 healthy controls. Patients with Active IBD had significantly lower intakes of numerous micronutrients, including iron, folate, and vitamin C, compared with controls. All IBD groups consumed less total fibre [4.5 to 5.8 g/day] than controls [p = 0.001], and total FODMAP and fructan intakes were lower in Active IBD compared with controls. Strikingly, FR-QoL was significantly lower in all IBD groups compared with controls [all p = 0.001].

conclusionsThis study revealed lower intakes of fibre, FODMAPs, and micronutrients, in addition to poorer FR-QoL, in Active IBD and Inactive IBD-GI with gut symptoms compared with healthy controls. Future research should address dietary restrictions responsible for these differences.

Indexed as

Dietary FiberEatingNutrientsSeverity of Illness IndexAdultCase-Control StudiesChronic DiseaseFemaleHumansInflammatory Bowel DiseasesMaleQuality of LifeDietary FiberNutrientsdietfood-related quality of lifeFR-QoLInflammatory bowel diseasenutrition

Identifiers

PMID34216206
PMCPMC8684455
OpenAlexW3174933896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.