ArticleAngewandte Chemie (International ed. in English)2021
Intermolecular [5+2] Annulation between 1-Indanones and Internal Alkynes by Rhodium-Catalyzed C-C Activation.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Modular esterification of unstrained carbonyls through palladium-catalyzed alkyne bridging C-C bond activation.Nature communications · 2025Article
- Article
- Ligand Design Enables the Palladium-Catalyzed Intermolecular Carbochlorocarbonylation of Alkynes and Cyclopentenone Formation.Journal of the American Chemical Society · 2025Article
- Synthesis of Benzo-Fused Cycloheptanones from Cyclobutanol Derivatives by a C-C Cleavage/Cross-Coupling/Enolate Arylation Sequence.Synthesis · 2025Article
- Skeletal Modification via Activation of Relatively Unstrained C-C Bonds.Accounts of chemical research · 2025Article
- Merging the Norrish type I reaction and transition metal catalysis: photo- and Rh-promoted borylation of C-C σ-bonds of aryl ketones.Chemical science · 2023Article
- Annulations involving 1-indanones to access fused- and spiro frameworks.RSC advances · 2022Review
- Deconstructive Synthesis of Bridged and Fused Rings via Transition-Metal-Catalyzed "Cut-and-Sew" Reactions of Benzocyclobutenones and Cyclobutanones.Accounts of chemical research · 2022Article
- Rapid syntheses of N-fused heterocycles via acyl-transfer in heteroaryl ketones.Nature communications · 2022Article
- Rhodium-Catalyzed (4+1) Cycloaddition between Benzocyclobutenones and Styrene-Type Alkenes.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
3 authors.
Funding
Abstract
Herein, we report a [5+2] cycloaddition between readily accessible 1-indanones and internal alkynes through Rh-catalyzed activation of less strained C-C bonds. The reaction is enabled by a strongly σ-donating NHC ligand and a carefully modified temporary directing group. A wide range of functional groups is tolerated, and the method provides straightforward access to diverse benzocycloheptenones that are hard to access otherwise. DFT studies of the reaction mechanism imply the migration insertion as the turnover-limiting step and suggest beneficial π-π interactions in the transition states.
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Registered trials
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