Evidence map›Paper›PMID 34216051›Full record

ArticleMagnetic resonance in medicine2021

Specialized computational methods for denoising, B

Philip M Lee, Hsin-Yu Chen, Jeremy W Gordon, Zihan Zhu, Peder E Z Larson, Nicholas Dwork, Mark Van Criekinge, Lucas Carvajal, Michael A Ohliger, Zhen J Wang and 6 more

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Ultra-low fieldCommunications chemistry · 2026
    Article
  2. Article
  3. Article
  4. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  5. Review
  6. Hyperpolarized carbon 13 MRI in liver diseases: Recent advances and future opportunities.Liver international : official journal of the International Association for the Study of the Liver · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Philip M LeeUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.ORCID 0000-0002-5783-1599
Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-2765-1685
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-2760-4886
Zihan ZhuUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.
Peder E Z LarsonUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.ORCID 0000-0003-4183-3634
Nicholas DworkDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-9838-4772
Mark Van CriekingeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Lucas CarvajalDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-6878-8189
Zhen J WangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Duan XuUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.ORCID 0000-0003-0550-4235
John KurhanewiczUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.ORCID 0000-0002-3544-5339
Robert A BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-1737-9056
Rahul AggarwalDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Pamela N MunsterDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Daniel B VigneronUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.ORCID 0000-0001-5795-8699
University of California, San Francisco · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Supplement for Development and Translation of Specialized Hyperpolarized C-13 MRI Methods for Alzheimer's DiseaseU01EB026412 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORDON, JEREMY WILLIAM, VIGNERON, DANIEL B · 2019 to 2023
$6.6M
Translating HP 13C MRI as a Novel Paradigm for Assessing Drug Target InhibitionR01CA183071 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HURD, RALPH EUGENE, MUNSTER, PAMELA N. · 2014 to 2018
$3.3M
Novel hyperpolarized 13C molecular imaging techniques for differentiating NAFLD and NASHR01DK115987 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OHLIGER, MICHAEL, VON MORZE, CORNELIUS · 2018 to 2022
$2.1M
NCI NIH HHS R01 CA183071NIBIB NIH HHS P41 EB013598NIBIB NIH HHS U01 EB026412NIDDK NIH HHS R01 DK115987
6 · The paper itself

Abstract

purposeTo develop a novel post-processing pipeline for hyperpolarized (HP)

methodsSeven HP

resultsDenoising averages SNR increases of pyruvate, lactate, and alanine were 37.4-, 34.0-, and 20.1-fold, respectively, with lactate and alanine dynamics most noticeably recovered and better defined. In agreement with Monte Carlo simulations, over-flipped regions underestimated k

conclusionThe new HP

Indexed as

Liver NeoplasmsMagnetic Resonance ImagingCarbon IsotopesEcho-Planar ImagingHumansKineticsPyruvic AcidCarbon IsotopesPyruvic AcidanalysisB1 correctionhyperpolarized 13C-pyruvate MR

Identifiers

PMID34216051
PMCPMC8565779
OpenAlexW3176463116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.