ArticleInfectious diseases and therapy2021
Predictors of Mortality and Drug Resistance Among Carbapenem-Resistant Enterobacteriaceae-Infected Pancreatic Necrosis Patients.
Article in Infectious diseases and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 20 citations in OpenAlex.
- Development and external evaluation of an interpretable machine-learning model for early prediction of organ failure in higher-risk acute pancreatitis patients: A multicentre cohort study.PLOS digital health · 2026Article
- Risk Factors Associated with the Emergence of Multidrug-Resistant Bacteria and Fungal Infections in Walled-Off Pancreatic Necrosis.Antibiotics (Basel, Switzerland) · 2026Article
- Microbiome therapeutic PMC101 inhibits the translocation of carbapenem-resistant Klebsiella while enhancing eubiosis in antibiotic-induced dysbiosis mice.Medical microbiology and immunology · 2025Article
- Development and validation of an explainable machine learning model for mortality prediction among patients with infected pancreatic necrosis.EClinicalMedicine · 2025Article
- Risk Factor Analysis and Molecular Epidemiological Investigation of Carbapenem-ResistantInfection and drug resistance · 2025Article
- Clinical Characteristics and Independent Risk Factors for Multidrug-ResistantInfection and drug resistance · 2025Article
- Epidemiology and clinical characteristics of patients with carbapenem-resistant enterobacterales infections: experience from a large tertiary care center in a developing country.BMC infectious diseases · 2023Article
- The impact of multi-drug resistant Pseudomonas aeruginosa infections on acute pancreatitis patients.BMC infectious diseases · 2023Article
- Clinical Characteristics, Drug Resistance, and Risk Factors for Death ofInfection and drug resistance · 2023Article
- Risk Factors for Mortality Among Critical Acute Pancreatitis Patients with Carbapenem-Resistant Organism Infections and Drug Resistance of Causative Pathogens.Infectious diseases and therapy · 2022Article
- Risk Factors for Carbapenem Resistant Gram Negative Bacteria (CR-GNB) Carriage Upon Admission to the Gastroenterology Department in a Tertiary First Class Hospital of China: Development and Assessment of a New Predictive Nomogram.Infection and drug resistance · 2022Article
- Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients.Frontiers in cellular and infection microbiology · 2022Article
- Clinical Outcomes and Microbiological Characteristics of Sequence Type 11Frontiers in medicine · 2022Article
- Blood Urea Nitrogen as a Prognostic Marker in Severe Acute Pancreatitis.Disease markers · 2022Article
- Predictors of mortality in acute pancreatitis complicated with multidrug-resistant Klebsiella pneumoniae infection.BMC infectious diseases · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionCarbapenem-resistant Enterobacteriaceae (CRE) has emerged as a global threat to hospitalization patients. Infected pancreatic necrosis (IPN) leads to high risks of CRE infections with increasing mortality. Our study aims to determine the predictors related to 90-day overall mortality of CRE IPN.
methodsWe retrospectively reviewed the drug resistance rates and clinical characteristics of CRE IPN patients from January 1, 2016, to January 1, 2021. Independent predictors of mortality were identified via univariate and multivariate analyses.
resultsDuring the 5-year period, 75 IPN patients suffered from 135 episodes of CRE infections with mortality up to 50.7%. CRE strains were highly resistant (> 50%) to nine of ten common antibiotics, except tigecycline (18%). The most common pathogen was carbapenem-resistant Klebsiella pneumoniae (84 of 135). Lung was the main site of extrapancreatic infections, followed by bloodstream and biliary tract. The independent predictors of mortality were Sequential Organ Failure Assessment (SOFA) score > 2 (hazard ratio 3.746, 95% confidence interval 1.209-11.609, P = 0.022) and procalcitonin > 6 ng/l (hazard ratio 2.428, 95% confidence interval 1.204-4.895, P = 0.013).
conclusionCRE is widespread as a global challenge with a high mortality rate among IPN patients due to limited therapeutic options. Carbapenem-resistant K. pneumoniae is the leading category of CRE which requires more attention in clinical practice. High SOFA score and procalcitonin level represent two independent predictors of mortality in CRE IPN patients. Greater efforts are needed toward timely therapeutic intervention for CRE IPN.
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