ArticleAnalytical and bioanalytical chemistry2021
Observation of charged droplets from electrospray ionization (ESI) plumes in API mass spectrometers.
Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Propionic Acid Outperforms Formic and Acetic Acid in MS Sensitivity for High-Flow Reversed-Phase LC-MS Bottom-Up Proteomics.Analytical chemistry · 2026Article
- Negative Gaseous Ions in Positive-Voltage Electrospray Ionization Mass Spectrometry.Analytical chemistry · 2026Article
- Simultaneous ManNAc and Neu5Ac Quantification in Human Sera by LC-MS/MS.International journal of molecular sciences · 2026Article
- Clean Electrospray Deposition of Porphyrin Molecules and Polyethylene Glycol Chains onto a Au(100) Surface.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026Article
- Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects.Nature methods · 2024Article
- Ion parking in native mass spectrometry.The Analyst · 2024Article
- High-Performance, Low-Cost, Additively Manufactured Electrospray Ion Sources for Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2024Article
- Moderate Signal Enhancement in Electrospray Ionization Mass Spectrometry by Focusing Electrospray Plume with a Dielectric Layer around the Mass Spectrometer's Orifice.Molecules (Basel, Switzerland) · 2024Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrospray ionization (ESI) generates bare analyte ions from charged droplets, which result from spraying a liquid in a strong electric field. Experimental observations available in the literature suggest that at least a significant fraction of the initially generated droplets remain large, have long lifetimes, and can thus aspirate into the inlet system of an atmospheric pressure ionization mass spectrometer (API-MS). We report on the observation of fragment signatures from charged droplets penetrating deeply the vacuum stages of three commercial mass spectrometer systems with largely different ion source and spray configurations. Charged droplets can pass through the ion source and pressure reduction stages and even into the mass analyzer region. Since droplet signatures were found in all investigated instruments, the incorporation of charged droplets is considered a general phenomenon occurring with common spray conditions in ESI sources.
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