Evidence map›Paper›PMID 34215904›Full record

ArticleApplied microbiology and biotechnology2021

Improved glucose and xylose co-utilization by overexpression of xylose isomerase and/or xylulokinase genes in oleaginous fungus Mucor circinelloides.

Xinyi Zan, Jianing Sun, Linfang Chu, Fengjie Cui, Shuhao Huo, Yuanda Song, Mattheos A G Koffas

Abstract read
PubMed Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Frontiers in bioengineering and biotechnology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyi ZanSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, People's Republic of China.
Jianing SunSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, People's Republic of China.
Linfang ChuSchool of Food Science and Technology, Jiang University, Wuxi, 214000, People's Republic of China.
Fengjie CuiSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, People's Republic of China.
Shuhao HuoSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, People's Republic of China.
Yuanda SongColin Ratledge Center for Microbial Lipids, School of Agriculture Engineering and Food Science, Shandong University of Technology, Zibo, 255049, People's Republic of China. ysong@sdut.edu.cn.ORCID http://orcid.org/0000-0002-8565-6724
Mattheos A G KoffasCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.

Funding

Chinese Postdoctoral Science Foundation 2019M661761National Natural Science Foundation of China 21978120National Natural Science Foundation of China 31670064Natural Science Foundation of Jiangsu Province BK20200889TaiShan Industrial Experts Program tscy 20160101
6 · The paper itself

Abstract

Most of the oleaginous microorganisms cannot assimilate xylose in the presence of glucose, which is the major bottleneck in the bioconversion of lignocellulose to biodiesel. Our present study revealed that overexpression of xylose isomerase (XI) gene xylA or xylulokinase (XK) gene xks1 increased the xylose consumption by 25 to 37% and enhanced the lipid content by 8 to 28% during co-fermentation of glucose and xylose. In xylA overexpressing strain Mc-XI, the activity of XI was 1.8-fold higher and the mRNA level of xylA at 24 h and 48 h was 11- and 13-fold higher than that of the control, respectively. In xks1 overexpressing strain Mc-XK, the mRNA level of xks1 was 4- to 11-fold of that of the control strain and the highest XK activity of 950 nmol min

Indexed as

GlucoseXyloseAldose-Ketose IsomerasesFermentationMucorPhosphotransferases (Alcohol Group Acceptor)Aldose-Ketose IsomerasesGlucosePhosphotransferases (Alcohol Group Acceptor)Xylosexylose isomerasexylulokinaseLipid productionMucor circinelloidesXylose isomeraseXylose utilizationXylulokinase

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.