Evidence map›Paper›PMID 34215868›Full record

ArticleAmerican journal of epidemiology2021

Combining Longitudinal Data From Different Cohorts to Examine the Life-Course Trajectory.

Rachael A Hughes, Kate Tilling, Deborah A Lawlor

Abstract read
In one paragraph

Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rachael A Hughes
Kate Tilling
Deborah A Lawlor

Funding

Breastfeeding RCT: Adolescent Neurocognitive and Respiratory FunctionR01HD050758 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI MARTIN, RICHARD MICHAEL, OKEN, EMILY · 2007 to 2014
$3.0M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
British Heart Foundation CS/16/4/32482Cancer Research UKCIHR MOP-53155Department of Health NF-0616-10102Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_PC_21038Medical Research Council MC_UU_00011/3Medical Research Council MC_UU_00011/6Medical Research Council MR/N024397/1NICHD NIH HHS K24 HD069408NICHD NIH HHS R01 HD050758Wellcome TrustWellcome Trust 215408/Z/19/ZWellcome Trust 217065/Z/19/ZWellcome Trust WT101597MA
6 · The paper itself

Abstract

Longitudinal data are necessary to reveal changes within an individual as he or she ages. However, rarely will a single cohort study capture data throughout a person's entire life span. Here we describe in detail the steps needed to develop life-course trajectories from cohort studies that cover different and overlapping periods of life. Such independent studies are probably from heterogenous populations, which raises several challenges, including: 1) data harmonization (deriving new harmonized variables from differently measured variables by identifying common elements across all studies); 2) systematically missing data (variables not measured are missing for all participants in a cohort); and 3) model selection with differing age ranges and measurement schedules. We illustrate how to overcome these challenges using an example which examines the associations of parental education, sex, and race/ethnicity with children's weight trajectories. Data were obtained from 5 prospective cohort studies (carried out in Belarus and 4 regions of the United Kingdom) spanning data collected from birth to early adulthood during differing calendar periods (1936-1964, 1972-1979, 1990-2012, 1996-2016, and 2007-2015). Key strengths of our approach include modeling of trajectories over wide age ranges, sharing of information across studies, and direct comparison of the same parts of the life course in different geographical regions and time periods. We also introduce a novel approach of imputing individual-level covariates of a multilevel model with a nonlinear growth trajectory and interactions.

Indexed as

Body-Weight TrajectoryData Interpretation, StatisticalLongitudinal StudiesAdolescentAge DistributionAgingChildChild, PreschoolFemaleHumansInfantLife Change EventsMaleProspective StudiesRepublic of BelarusSociodemographic FactorsAvon Longitudinal Study of Parents and ChildrenBarry Caerphilly Growth StudyBorn in Bradford StudyChrist’s Hospital School Studylife coursemixed-effects modelsPromotion of Breastfeeding Intervention Trialrepeated measures

Identifiers

PMID34215868
PMCPMC8634562

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.