ArticlePediatric research2022
Degree of ventriculomegaly predicts school-aged functional outcomes in preterm infants with intraventricular hemorrhage.
Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Post-hemorrhagic ventricular dilatation: Comparison of management pathways among North American level IV NICUs.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neurodevelopmental impairment in preterm infants following progressive post-hemorrhagic ventricular dilatation.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Post-hemorrhagic ventricular dilatation in preterm infants: maximal ventricular dilatation and timing of intervention predict neurodevelopment.Pediatric research · 2026Article
- Changes of head circumference and ventricular width in infant hydrocephalus managed with adjustable shunt valves and gravitational assistance-a comparative bi-center study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Neuroendoscopic lavage: a single-center retrospective cohort in the USA.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Neurodevelopmental outcome of perinatal intracranial haemorrhage in patients born at term: A prospective study.Developmental medicine and child neurology · 2025Observational
- Cranial Ultrasonography-Standards in Diagnosis of Intraventricular Hemorrhage and Ventricular Dilatation in Premature Neonates.Children (Basel, Switzerland) · 2025Review
- Prediction of post-hemorrhagic ventricular dilatation trajectory using a growth mixture model in preterm infants.Pediatric research · 2025Article
- Spontaneous resolution of post-hemorrhagic ventricular dilatation in preterm newborns and neurodevelopment.Pediatric research · 2023Article
- Nonhematopoietic Umbilical Cord Blood Stem Cell Administration Improves Long-term Neurodevelopment After Periventricular-Intraventricular Hemorrhage in Neonatal Rats.Cell transplantationArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGreater ventriculomegaly in preterm infants with intraventricular hemorrhage (IVH) has been associated with worse neurodevelopmental outcomes in infancy. We aim to explore the relationship between ventriculomegaly and school-age functional outcome.
methodsRetrospective review of preterm infants with Grade III/IV IVH from 2006 to 2020. Frontal-occipital horn ratio (FOHR) was measured on imaging throughout hospitalization and last available follow-up scan. Pediatric Cerebral Performance Category (PCPC) scale was used to assess functional outcome at ≥4 years. Ordinal logistic regression was used to determine the relationship between functional outcome and FOHR at the time of Neurosurgery consult, neurosurgical intervention, and last follow-up scan while adjusting for confounders.
resultsOne hundred and thirty-four infants had Grade III/IV IVH. FOHR at consult was 0.62 ± 0.12 and 0.75 ± 0.13 at first intervention (p < 0.001). On univariable analysis, maximum FOHR, FOHR at the last follow-up scan, and at Neurosurgery consult predicted worse functional outcome (p < 0.01). PVL, longer hospital admission, and gastrotomy/tracheostomy tube also predicted worse outcome (p < 0.05). PVL, maximum FOHR, and FOHR at consult remained significant on multivariable analysis (p < 0.05). Maximum FOHR of 0.61 is a fair predictor for moderate-severe impairment (AUC 75%, 95% CI: 62-87%).
conclusionsGreater ventricular dilatation and PVL were independently associated with worse functional outcome in Grade III/IV IVH regardless of neurosurgical intervention. IMPACT: Ventriculomegaly measured by frontal-occipital horn ratio (FOHR) and periventricular leukomalacia are independent correlates of school-age functional outcomes in preterm infants with intraventricular hemorrhage regardless of need for neurosurgical intervention. These findings extend the known association between ventriculomegaly and neurodevelopmental outcomes in infancy to functional outcomes at school age. FOHR is a fair predictor of school-age functional outcome, but there are likely other factors that influence functional status, which highlights the need for prospective studies to incorporate other clinical and demographic variables in predictive models.
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