Evidence map›Paper›PMID 34215830›Full record

ArticleCommunications biology2021

FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression.

Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner and 10 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. ReliableMolecules (Basel, Switzerland) · 2023
    Article
  4. Review
  5. Skin-homing basophils and beyond.Frontiers in immunology · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Kia Joo Puan *Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.ORCID 0000-0003-2445-3154
Boris San Luis *Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
Nurhashikin YusofSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
Dilip KumarSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.ORCID 0000-0002-1848-3034
Anand Kumar AndiappanSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.ORCID 0000-0002-8442-1544
Wendy LeeSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
Samanta CajicMax Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.ORCID 0000-0001-5820-0732
Dragana VuckovicDepartment of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.
Jing De ChanSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.ORCID 0000-0002-2249-5273
Tobias DöllnerSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
Han Wei HouLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0001-6631-6321
Yunxuan Jiang23andMe, Inc., Sunnyvale, CA, USA.
Chao Tian23andMe, Inc., Sunnyvale, CA, USA.
23andMe Research Team
Erdmann RappMax Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.ORCID 0000-0001-6618-2626
Michael PoidingerSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.ORCID 0000-0002-1047-2277
De Yun WangDepartment of Otolaryngology, National University of Singapore, Singapore, Singapore.
Nicole SoranzoDepartment of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.ORCID 0000-0003-1095-3852
Bernett LeeSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
Olaf RötzschkeSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore. olaf_rotzschke@immunol.a-star.edu.sg.ORCID 0000-0001-8336-5248
23andMe (United States) · USAgency for Science, Technology and Research · SGMax Planck Institute for Dynamics of Complex Technical Systems · DEWellcome Sanger Institute · GBNanyang Technological University · SGNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sialyl-Lewis x (sLe

Indexed as

Gene ExpressionBase SequenceBasophilsCells, CulturedCohort StudiesE-SelectinFucosyltransferasesGene Expression ProfilingHumansLeukocyte CountLeukocyte RollingPolymorphism, Single NucleotideSequence Homology, Nucleic AcidSialyl Lewis X AntigenE-SelectinFucosyltransferasesFUT6 protein, humanSELE protein, humanSialyl Lewis X Antigen

Identifiers

PMID34215830
PMCPMC8253766
OpenAlexW3174941782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.