Evidence map›Paper›PMID 34215769›Full record

SynthesisScientific reports2021

Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review.

Nan Zhang, Jiaxing Wang, Ying Li, Bing Jiang

2 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 183 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 12 pooled it
44.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06498440 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Comparative Efficacy of NSAID and Steroid-NSAID Combination Following Selective Laser Trabeculoplasty: a Phase 4, Single-centre, Randomized Controlled Trial

TypeinterventionalSponsorSt. Joseph's Healthcare HamiltonRan2024 to 2025Enrolled126ConditionsOpen Angle Glaucoma, Ocular Hypertension, Postoperative InflammationArmsKetorolac 0.5% Eye Drops, Ketorolac 0.5% and Fluorometholone 0.1% Eye Drops
NCT07152132 narecruitingnot on this mapstarted 2025, after this paper: background citation

Slow Coagulation Trans-Scleral Cyclophotocoagulation Versus Trabeculectomy in Medically Uncontrolled Open-Angle Glaucoma in Pseudophakic Patients

TypeinterventionalSponsorMinia UniversityRan2025 to 2026Enrolled50ConditionsGlaucoma, Open AngleArmsTrabeculectomy, Slow coagulation trans-scleral cyclophotocoagulation
3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 12 syntheses or guidelines pooled it, 331 citations in OpenAlex.

  1. Minimally invasive trabecular meshwork surgery for open-angle glaucoma.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Computational study of DurystaDrug delivery and translational research · 2026
    Article
  19. Article
  20. Article

123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Nan Zhang *Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Jiaxing Wang *Department of Ophthalmology, School of Medicine, Emory University, Atlanta, GA, USA.
Ying LiDepartment of Ophthalmology, School of Medicine, Emory University, Atlanta, GA, USA.
Bing JiangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. drjiangb@csu.edu.cn.
Emory University · USCentral South University · CNHunan Provincial Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness in the world and is influenced by various sociodemographic factors. This meta-analysis aims to determine the worldwide prevalence of POAG in the adult general population for the last 20 years, and explore variation in prevalence by age, gender and geographical location. An electronic literature search was performed using the PubMed, Embase, and Web of Science databases. Population-based cross-sectional or cohort studies published in the last 20 years (2000-2020) that reported prevalence of POAG were recruited. Relevant studies meeting defined eligibility criteria were selected and reviewed systematically by meta-analysis. The prevalence of POAG was analyzed according to various risk factors. A random effect model was used for the meta-analysis. Fifty publications with a total of 198,259 subjects were included in this meta-analysis. The worldwide overall prevalence of POAG was 2.4% (95% CI 2.0 ~ 2.8%). The prevalence increases with age. Men are found to be more susceptible to POAG than women (RR 1.28, p < 0.01). Africa is found to have the highest prevalence of POAG (4.0%) among all continents. The current estimated global population of POAG is 68.56 million (95% CI 59.99 ~ 79.98). POAG is a worldwide vision threatening disease with high prevalence for the last 20 years. The population-based prevalence of POAG varies widely across individual studies, due to variations in risk factors of age, gender, and population geographic location.

Indexed as

PrevalenceAfricaAge DistributionBlindnessCross-Sectional StudiesFemaleGlaucoma, Open-AngleHumansMaleRisk FactorsSex Distribution

Identifiers

PMID34215769
PMCPMC8253788
OpenAlexW3173654426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.