ArticleScientific reports2021
Livelayer: a semi-automatic software program for segmentation of layers and diabetic macular edema in optical coherence tomography images.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Comparative Analysis of Deep Learning Architectures for Macular Hole Segmentation in OCT Images: A Performance Evaluation of U-Net Variants.Journal of imaging · 2025Article
- Assessment of area and structural irregularity of retinal layers in diabetic retinopathy using machine learning and image processing techniques.Scientific reports · 2024Article
- The effect of optical degradation from cataract using a new Deep Learning optical coherence tomography segmentation algorithm.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Optimal Deep Learning Architecture for Automated Segmentation of Cysts in OCT Images Using X-Let Transforms.Diagnostics (Basel, Switzerland) · 2023Article
- Mixed multiscale BM4D for three-dimensional optical coherence tomography denoising.Computers in biology and medicine · 2023Article
- Automated assessment of the smoothness of retinal layers in optical coherence tomography images using a machine learning algorithm.BMC medical imaging · 2023Article
- Artificial Intelligence in Medicine.Journal of biomedical physics & engineering · 2022Article
- Synthetic OCT Data Generation to Enhance the Performance of Diagnostic Models for Neurodegenerative Diseases.Translational vision science & technology · 2022Article
- Synthetic OCT data in challenging conditions: three-dimensional OCT and presence of abnormalities.Medical & biological engineering & computing · 2022Article
- Loss-Modified Transformer-Based U-Net for Accurate Segmentation of Fluids in Optical Coherence Tomography Images of Retinal Diseases.Journal of medical signals and sensorsArticle
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10 authors.
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Abstract
Given the capacity of Optical Coherence Tomography (OCT) imaging to display structural changes in a wide variety of eye diseases and neurological disorders, the need for OCT image segmentation and the corresponding data interpretation is latterly felt more than ever before. In this paper, we wish to address this need by designing a semi-automatic software program for applying reliable segmentation of 8 different macular layers as well as outlining retinal pathologies such as diabetic macular edema. The software accommodates a novel graph-based semi-automatic method, called "Livelayer" which is designed for straightforward segmentation of retinal layers and fluids. This method is chiefly based on Dijkstra's Shortest Path First (SPF) algorithm and the Live-wire function together with some preprocessing operations on the to-be-segmented images. The software is indeed suitable for obtaining detailed segmentation of layers, exact localization of clear or unclear fluid objects and the ground truth, demanding far less endeavor in comparison to a common manual segmentation method. It is also valuable as a tool for calculating the irregularity index in deformed OCT images. The amount of time (seconds) that Livelayer required for segmentation of Inner Limiting Membrane, Inner Plexiform Layer-Inner Nuclear Layer, Outer Plexiform Layer-Outer Nuclear Layer was much less than that for the manual segmentation, 5 s for the ILM (minimum) and 15.57 s for the OPL-ONL (maximum). The unsigned errors (pixels) between the semi-automatically labeled and gold standard data was on average 2.7, 1.9, 2.1 for ILM, IPL-INL, OPL-ONL, respectively. The Bland-Altman plots indicated perfect concordance between the Livelayer and the manual algorithm and that they could be used interchangeably. The repeatability error was around one pixel for the OPL-ONL and < 1 for the other two. The unsigned errors between the Livelayer and the manual algorithm was 1.33 for ILM and 1.53 for Nerve Fiber Layer-Ganglion Cell Layer in peripapillary B-Scans. The Dice scores for comparing the two algorithms and for obtaining the repeatability on segmentation of fluid objects were at acceptable levels.
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