ArticleNPJ biofilms and microbiomes2021
Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation.
Article in NPJ biofilms and microbiomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 86 citations in OpenAlex.
- Temporal dynamics of gut biosynthetic gene clusters link persistent colonization and engraftment in fecal microbiota transplantation.Gut microbes · 2026Article
- Diverse biosynthetic pathways in Arctic hydrothermal biofilms.Nature communications · 2026Article
- Oxidative stress inducesMicrobiology spectrum · 2026Article
- Phenotypic and genomic insights into Stenotrophomonas sepilia SMBL8: metabolic versatility, antibiotic resistance and pathogenic potential.World journal of microbiology & biotechnology · 2026Article
- Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm-Mediated Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genomic and phenotypic insights into Pseudocolwellia antarctica sp. nov., a novel psychrotolerant bacterium with symbiotic potential from Antarctic zooplankton.Scientific reports · 2026Article
- Whole-genome analysis of Pantoea alfalfae HF1 isolated from shot hole lesions in peach leaves and symptom reproduction by wound inoculation.AMB Express · 2026Article
- Genomic insights into 'Candidatus Pseudomonas auctus' JDE115, a soybean endophyte with expanded nutrient acquisition and biocontrol-related gene repertoires.BMC genomics · 2026Article
- Genomic and phenotypic characterization of Vibrio cholerae strain SU109: a genomic investigation of a shrimp-associated strain from Bangladesh.BMC genomics · 2026Article
- Human body temperature cues widespread changes in virulence gene expression in uropathogenicInfection and immunity · 2026Article
- Flavoaffinins, Elusive Cellulose-Binding Natural Products from an Anaerobic Bacterium.Journal of the American Chemical Society · 2026Article
- Genome-resolved metagenomics uncovers diversity and functional landscapes of the gastrointestinal epithelium-associated microbiome in cattle.Genome biology · 2026Article
- Oxidative stress inducesbioRxiv : the preprint server for biology · 2026Article
- The biosynthetic gene cluster landscape of the oral microbiome across health and dental caries.Journal of industrial microbiology & biotechnology · 2026Article
- Article
- Article
- Draft genome sequence of an Acinetobacter albensis strain from untreated wastewater.Access microbiology · 2026Article
- Structural and dynamic roles of tandem acyl carrier proteins in aryl polyene biosynthesis in carbapenem-resistant Acinetobacter baumannii.Protein science : a publication of the Protein Society · 2025Article
- Integrated genomic and mutagenesis analysis of Pseudomonas argentinensis SA190 reveals mechanisms of plant root colonization and stress resilience.BMC microbiology · 2025Article
- Isolation of Halophilic and Halotolerant Bacterial Strains, Screening for Bioactive Compounds and Characterisation of Metabolites Produced by Pseudoalteromonas sp. ASV78.Environmental microbiology reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Aryl polyenes (APEs) are specialized polyunsaturated carboxylic acids that were identified in silico as the product of the most widespread family of bacterial biosynthetic gene clusters (BGCs). They are present in several Gram-negative host-associated bacteria, including multidrug-resistant human pathogens. Here, we characterize a biological function of APEs, focusing on the BGC from a uropathogenic Escherichia coli (UPEC) strain. We first perform a genetic deletion analysis to identify the essential genes required for APE biosynthesis. Next, we show that APEs function as fitness factors that increase protection from oxidative stress and contribute to biofilm formation. Together, our study highlights key steps in the APE biosynthesis pathway that can be explored as potential drug targets for complementary strategies to reduce fitness and prevent biofilm formation of multi-drug resistant pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.