Evidence map›Paper›PMID 34215693›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The narrowing of dendrite branches across nodes follows a well-defined scaling law.

Maijia Liao, Xin Liang, Jonathon Howard

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maijia LiaoDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520.ORCID 0000-0003-4396-8831
Xin LiangTsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Jonathon HowardDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520; joe.howard@yale.edu.ORCID 0000-0003-0086-1196

Funding

Cell Biological Limitations Constrain Dendritic Branching Morphology and Neuronal FunctionDP1MH110065 · NIMH · YALE UNIVERSITY · PI HOWARD, JONATHON · 2015 to 2019
$4.2M
Dendrite structure: Data-Driven Models to Bridge from Molecules to MorphologyR01NS118884 · NINDS · YALE UNIVERSITY · PI HOWARD, JONATHON · 2021 to 2025
$2.0M
NIMH NIH HHS DP1 MH110065NINDS NIH HHS R01 NS118884
6 · The paper itself

Abstract

The systematic variation of diameters in branched networks has tantalized biologists since the discovery of da Vinci's rule for trees. Da Vinci's rule can be formulated as a power law with exponent two: The square of the mother branch's diameter is equal to the sum of the squares of those of the daughters. Power laws, with different exponents, have been proposed for branching in circulatory systems (Murray's law with exponent 3) and in neurons (Rall's law with exponent 3/2). The laws have been derived theoretically, based on optimality arguments, but, for the most part, have not been tested rigorously. Using superresolution methods to measure the diameters of dendrites in highly branched

Indexed as

Models, BiologicalAnimalsCytoskeletonDendritesDrosophila melanogasterallometrybiological networksmicrotubule transportoptimality

Identifiers

PMID34215693
PMCPMC8271565

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.