Evidence map›Paper›PMID 34215692›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Loss of function of a DMR6 ortholog in tomato confers broad-spectrum disease resistance.

Daniela Paula de Toledo Thomazella, Kyungyong Seong, Rebecca Mackelprang, Douglas Dahlbeck, Yu Geng, Upinder S Gill, Tiancong Qi, Julie Pham, Priscila Giuseppe, Clara Youngna Lee and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
40.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 250 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Beyond Resistance Genes: Silencing Susceptibility.International journal of molecular sciences · 2026
    Review
  11. Article
  12. From Lab to Field: CRISPRing Major CultivatedInternational journal of molecular sciences · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Genome editing of susceptibility geneFrontiers in plant science · 2026
    Article
  17. Article
  18. Article
  19. Review
  20. Review

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Daniela Paula de Toledo ThomazellaDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.ORCID 0000-0003-2041-8714
Kyungyong SeongDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-7711-0107
Rebecca MackelprangDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-2851-3823
Douglas DahlbeckDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.
Yu GengDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-1139-5971
Upinder S GillDepartment of Plant Pathology, North Dakota State University, Fargo, ND 58108.ORCID 0000-0003-4572-5243
Tiancong QiDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.ORCID 0000-0003-1971-2481
Julie PhamInnovative Genomics Institute, University of California, Berkeley, CA 94704.
Priscila GiuseppeBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas SP 13083-100, Brazil.ORCID 0000-0003-2094-7325
Clara Youngna LeeDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-9402-4155
Arturo OrtegaDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.ORCID 0000-0001-7114-9791
Myeong-Je ChoInnovative Genomics Institute, University of California, Berkeley, CA 94704.ORCID 0000-0002-7638-7235
Samuel F HuttonHorticultural Sciences Department, University of Florida, Gulf Coast Research and Education Center, Wimauma, FL 33598.ORCID 0000-0002-1635-4861
Brian StaskawiczDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720; stask@berkeley.edu.ORCID 0000-0002-9711-3962
Innovative Genomics Institute · USUniversity of California, Berkeley · USBrazilian Center for Research in Energy and Materials · BRNorth Dakota State University · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant diseases are among the major causes of crop yield losses around the world. To confer disease resistance, conventional breeding relies on the deployment of single resistance (R) genes. However, this strategy has been easily overcome by constantly evolving pathogens. Disabling susceptibility (S) genes is a promising alternative to R genes in breeding programs, as it usually offers durable and broad-spectrum disease resistance. In

Indexed as

Sequence Homology, Amino AcidArabidopsis ProteinsBiocatalysisDisease ResistanceGene Expression Regulation, PlantGentisatesMutationPhylogenyPlant DiseasesPlant ImmunityPlant ProteinsPlants, Genetically ModifiedSalicylic AcidSolanum lycopersicumTranscriptomeUp-Regulation2,5-dihydroxybenzoic acidArabidopsis ProteinsGentisatesPlant ProteinsSalicylic AcidCRISPR/Cas9 technologycrop engineeringdisease resistanceDMR6salicylic acid

Identifiers

PMID34215692
PMCPMC8271637
OpenAlexW3176823624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.