Evidence map›Paper›PMID 34215679›Full record

ArticleScience immunology2021

The m

Rami Bechara, Nilesh Amatya, Rachel D Bailey, Yang Li, Felix E Y Aggor, De-Dong Li, Chetan V Jawale, Bianca M Coleman, Ning Dai, Nandan S Gokhale and 6 more

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. The RNA methyltransferase NSUN2 catalyzes 5-methylcytosine (mThe Journal of biological chemistry · 2026
    Article
  7. Targeted Inhibition of CD74Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Mitigation of Ferroptosis in Diabetic Kidney Disease Through Mesenchymal Stem Cell Intervention via the Smad2/3/METTL3/S1PR1 Axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  13. Article
  14. Review
  15. IMPlications of IMP2 in RNA Biology and Disease.International journal of molecular sciences · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Rami BecharaDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1611-0242
Nilesh AmatyaDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7942-1742
Rachel D BaileyDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-2046-2339
Yang LiDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6743-4004
Felix E Y AggorDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0327-0095
De-Dong LiDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9474-390X
Chetan V JawaleDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-4621-6686
Bianca M ColemanDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-4276-7456
Ning DaiDiabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Nandan S GokhaleDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-4459-4053
Tiffany C TaylorDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4971-3728
Stacy M HornerDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-9351-7409
Amanda C PoholekDivision of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-5587-8940
Anita BansalDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-3235-9942
Partha S BiswasDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4570-7443
Sarah L GaffenDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA. sarah.gaffen@pitt.edu.ORCID 0000-0001-8511-2041
University of Pittsburgh · USDuke Medical Center · USMassachusetts General Hospital · US

Funding

Host and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6M
Defining the role of the RNA modification N6-methyladenosine in the hepatitis C virus lifecycleR01AI125416 · NIAID · DUKE UNIVERSITY · PI Stacy Michelle Horner · 2016 to 2026
$5.5M
Molecular Mechanisms of IL-17-dependent autoimmune signalingR01AI147383 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2020 to 2024
$2.6M
Mechanisms of neutrophil dysfunction in antifungal immunityR01AI142354 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BISWAS, PARTHA SARATHI, NOLIN, THOMAS DOUGLAS · 2019 to 2023
$2.4M
IL-17 Receptor Signaling in the Oral MucosaR01DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2012 to 2016
$2.1M
Negative Control of IL-17R Signaling: Implications for Fungal ImmunityR01AI107825 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2014 to 2018
$1.9M
Mechanisms of IL-17 Mediated Host Defense in the KidneyR01DK104680 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BISWAS, PARTHA SARATHI · 2015 to 2019
$1.5M
NIAID NIH HHS R01 AI107825NIAID NIH HHS R01 AI125416NIAID NIH HHS R01 AI142354NIAID NIH HHS R01 AI147383NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R37 DE022550NIDDK NIH HHS R01 DK104680
6 · The paper itself

Abstract

Excessive cytokine activity underlies many autoimmune conditions, particularly through the interleukin-17 (IL-17) and tumor necrosis factor-α (TNFα) signaling axis. Both cytokines activate nuclear factor κB, but appropriate induction of downstream effector genes requires coordinated activation of other transcription factors, notably, CCAAT/enhancer binding proteins (C/EBPs). Here, we demonstrate the unexpected involvement of a posttranscriptional "epitranscriptomic" mRNA modification [N6-methyladenosine (m

Indexed as

AdenosineAnimalsAutoimmunityCCAAT-Enhancer-Binding ProteinsCell LineFemaleHumansInflammationInterleukin-17MaleMiceMice, Inbred C57BLMice, KnockoutRNA-Binding ProteinsTumor Necrosis Factor-alphaAdenosineCCAAT-Enhancer-Binding ProteinsIGF2BP2 protein, mouseInterleukin-17N-methyladenosineRNA-Binding ProteinsTnf protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID34215679
PMCPMC8404281
OpenAlexW3174569344

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.