Evidence map›Paper›PMID 34215607›Full record

ArticleBMJ open2021

Toshihiko Kakiuchi, Yoshiki Tanaka, Hiroshi Ohno, Muneaki Matsuo, Kazuma Fujimoto

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. The impact ofFrontiers in cellular and infection microbiology · 2025
    Pooled it
  2. Beyond the Stomach: Exploring the Role ofExpert reviews in molecular medicine · 2026
    Review
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  4. Article
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  6. Commentary: Association betweenFrontiers in endocrinology · 2023
    Article
  7. Relationship betweenFrontiers in cellular and infection microbiology · 2022
    Review
  8. Important Recommendations Regarding the Test-and-Treat Strategy forInquiry : a journal of medical care organization, provision and financing
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Toshihiko KakiuchiDepartment of Pediatrics, Saga University, Saga, Japan kakiucht@cc.saga-u.ac.jp.ORCID 0000-0002-9995-5522
Yoshiki TanakaR&D Center, Biofermin Pharmaceutical Co Ltd, Kobe, Hyogo, Japan.
Hiroshi OhnoR&D Center, Biofermin Pharmaceutical Co Ltd, Kobe, Hyogo, Japan.
Muneaki MatsuoDepartment of Pediatrics, Saga University, Saga, Japan.
Kazuma FujimotoDepartment of Gastroenterology, International University of Health and Welfare, Ohkawa, Fukuoka, Japan.
Saga University · JPInternational University of Health and Welfare · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe relationship between

designCross-sectional study. SETTING AND

participantsWe included subjects from a longitudinal project involving

interventionsThe intestinal microbiota was evaluated in stool specimens using 16S rRNA gene/DNA/amplicon sequencing with next-generation sequencing. PRIMARY AND SECONDARY OUTCOME MEASURES: We assessed alpha and beta diversity, just as well as relative abundances within the bacterial composition at the genus level in both groups.

resultsAs shown by the alpha diversity of the 16S rRNA gene/DNA/amplicon sequence data, the control group exhibited lower microbial species richness with lower alpha diversity compared with the

conclusionTRIAL REGISTRATION NUMBER: UMIN000028721.

Indexed as

Gastrointestinal MicrobiomeHelicobacter InfectionsHelicobacter pyloriAdolescentChildCross-Sectional StudiesHumansJapanRNA, Ribosomal, 16SRNA, Ribosomal, 16S16S rRNAbody mass indexPrevotellagenusscreening and treatment

Identifiers

PMID34215607
PMCPMC8256750
OpenAlexW3177111192

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.