ArticleScience advances2021
Single-cell damagenome profiling unveils vulnerable genes and functional pathways in human genome toward DNA damage.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Mutagen-induced somatic mutation rate in primary mammalian cells in relation to maximum life span.Geromedicine · 2026Article
- Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Nature reviews. Genetics · 2025Review
- Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability.Nature methods · 2025Article
- Genome-wide profiling of DNA repair proteins in single cells.Nature communications · 2024Article
- Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders.International journal of molecular sciences · 2024Review
- The broken Alzheimer's disease genome.Cell genomics · 2024Review
- Article
- Extension of bacterial rDNA sequencing for simultaneous methylation detection and its application in microflora analysis.Scientific reports · 2023Article
- Fungal Strains with Identical Genomes Were Found at a Distance of 2000 Kilometers after 40 Years.Journal of fungi (Basel, Switzerland) · 2022Article
- Non-random genetic alterations in the cyanobacterium Nostoc sp. exposed to space conditions.Scientific reports · 2022Article
- Single-cell Damagenome Profiling by Linear Copying and Splitting based Whole Genome Amplification (LCS-WGA).Bio-protocol · 2022Article
- Structural and Evolutionary Adaptations of Nei-Like DNA Glycosylases Proteins Involved in Base Excision Repair of Oxidative DNA Damage in Vertebrates.Oxidative medicine and cellular longevity · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We report a novel single-cell whole-genome amplification method (LCS-WGA) that can efficiently capture spontaneous DNA damage existing in single cells. We refer to these damage-associated single-nucleotide variants as "damSNVs," and the whole-genome distribution of damSNVs as the damagenome. We observed that in single human neurons, the damagenome distribution was significantly correlated with three-dimensional genome structures. This nonuniform distribution indicates different degrees of DNA damage effects on different genes. Next, we identified the functionals that were significantly enriched in the high-damage genes. Similar functionals were also enriched in the differentially expressed genes (DEGs) detected by single-cell transcriptome of both Alzheimer's disease (AD) and autism spectrum disorder (ASD). This result can be explained by the significant enrichment of high-damage genes in the DEGs of neurons for both AD and ASD. The discovery of high-damage genes sheds new lights on the important roles of DNA damage in human diseases and disorders.
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