Evidence map›Paper›PMID 34215538›Full record

ReviewSeminars in fetal & neonatal medicine2021

Management of comfort and sedation in neonates with neonatal encephalopathy treated with therapeutic hypothermia.

Christopher McPherson, Adam Frymoyer, Cynthia M Ortinau, Steven P Miller, Floris Groenendaal, Newborn Brain Society Guidelines and Publications Committee

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in fetal & neonatal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Article
  8. Article
  9. Effectiveness and Safety of Dexmedetomidine in Neonates With Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Christopher McPhersonDepartment of Pediatrics, Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO, 63110, USA. Electronic address: mcphersonc@wustl.edu.
Adam FrymoyerDepartment of Pediatrics, Stanford University, 750 Welch Road, Suite 315, Palo Alto, CA, 94304, USA. Electronic address: frymoyer@stanford.edu.
Cynthia M OrtinauDepartment of Pediatrics, Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO, 63110, USA. Electronic address: ortinau_c@wustl.edu.
Steven P MillerDepartment of Pediatrics, The Hospital for Sick Children and the University of Toronto, 555 University Avenue, Toronto, ON, Canada. Electronic address: steven.miller@sickkids.ca.
Floris GroenendaalDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Lundlaan 6, 3584 EA, Utrecht, Netherlands. Electronic address: f.groenendaal@umcutrecht.nl.
Newborn Brain Society Guidelines and Publications Committee
Washington University in St. Louis · USSickKids Foundation · CAStanford University · USUtrecht University · NL

Funding

Physiologic and Genetic Contributions of Impaired Fetal Brain Development in Congenital Heart DiseaseK23HL141602 · NHLBI · WASHINGTON UNIVERSITY · PI ORTINAU, CYNTHIA MARIE · 2019 to 2022
$727k
NHLBI NIH HHS K23 HL141602
6 · The paper itself

Abstract

Ensuring comfort for neonates undergoing therapeutic hypothermia (TH) after neonatal encephalopathy (NE) exemplifies a vital facet of neonatal neurocritical care. Physiologic markers of stress are frequently present in these neonates. Non-pharmacologic comfort measures form the foundation of care, benefitting both the neonate and parents. Pharmacological sedatives may also be indicated, yet have the potential to both mitigate and intensify the neurotoxicity of a hypoxic-ischemic insult. Morphine represents current standard of care with a history of utilization and extensive pharmacokinetic data to guide safe and effective dosing. Dexmedetomidine, as an alternative to morphine, has several appealing characteristics, including neuroprotective effects in animal models; robust pharmacokinetic studies in neonates with NE treated with TH are required to ensure a safe and effective standard dosing approach. Future studies in neonates treated with TH must address comfort, adverse events, and long-term outcomes in the context of specific sedation practices.

Indexed as

AnesthesiaHypothermia, InducedHypoxia-Ischemia, BrainInfant, Newborn, DiseasesHumansInfant, NewbornMorphineMorphineDexmedetomidineInduced hypothermiaMorphineNeonatal encephalopathyNewborn infantSedation

Identifiers

PMID34215538
PMCPMC8900710
OpenAlexW3173269847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.