ArticleSchizophrenia research2021
Lower functional connectivity of white matter during rest and working memory tasks is associated with cognitive impairments in schizophrenia.
Article in Schizophrenia research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Processing Speed Impairment in Schizophrenia: An Updated Systematic Review and Meta-Analysis.JAMA psychiatry · 2026Pooled it
- The nature and interpretation of BOLD signals in white matter - A review.Magnetic resonance imaging · 2026Review
- Revealing multiple biological subtypes of schizophrenia through a data-driven approach.Journal of translational medicine · 2025Article
- Functional connectivity between the uncinate fasciculus and frontotemporal semantic system supports reading comprehension in adolescents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional correlation tensors in brain white matter and the effects of normal aging.Brain imaging and behavior · 2024Article
- The missing third dimension-Functional correlations of BOLD signals incorporating white matter.Science advances · 2024Article
- Whole-brain, gray, and white matter time-locked functional signal changes with simple tasks and model-free analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Functional alterations in bipartite network of white and grey matters during aging.NeuroImage · 2023Article
- Automatic Preprocessing Pipeline for White Matter Functional Analyses of Large-Scale Databases.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Detection of functional activity in brain white matter using fiber architecture informed synchrony mapping.NeuroImage · 2022Article
- Combined functional and structural imaging of brain white matter reveals stage-dependent impairment in multiple system atrophy of cerebellar type.NPJ Parkinson's disease · 2022Article
- Anomalous and heterogeneous characteristics of the BOLD hemodynamic response function in white matter.Cerebral cortex communications · 2022Article
- Power spectra reveal distinct BOLD resting-state time courses in white matter.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Diffusion-informed spatial smoothing of fMRI data in white matter using spectral graph filters.NeuroImage · 2021Article
- Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer's disease.PloS one · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSchizophrenia can be understood as a disturbance of functional connections within brain networks. However, functional alterations that involve white matter (WM) specifically, or their cognitive correlates, have seldomly been investigated, especially during tasks.
methodsResting state and task fMRI images were acquired on 84 patients and 67 controls. Functional connectivities (FC) between 46 WM bundles and 82 cortical regions were compared between the groups under two conditions (i.e., resting state and during working memory retention period). The FC density of each WM bundle was then compared between groups. Associations of FC with cognitive scores were evaluated.
resultsFC measures were lower in schizophrenia relative to controls for external capsule, cingulum (cingulate and hippocampus), uncinate fasciculus, as well as corpus callosum (genu and body) under the rest or the task condition, and were higher in the posterior corona radiata and posterior thalamic radiation during the task condition. FC for specific WM bundles was correlated with cognitive performance assessed by working memory and processing speed metrics.
conclusionsThe findings suggest that the functional abnormalities in patients' WM are heterogeneous, possibly reflecting several underlying mechanisms such as structural damage, functional compensation and excessive effort on task, and that WM FC disruption may contribute to the impairments of working memory and processing speed. This is the first report on WM FC abnormalities in schizophrenia relative to controls and their cognitive associates during both rest and task and highlights the need to consider WM functions as components of brain functional networks in schizophrenia.
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