ArticleWorld journal of emergency surgery : WJES2021
Multidisciplinary management of elderly patients with rectal cancer: recommendations from the SICG (Italian Society of Geriatric Surgery), SIFIPAC (Italian Society of Surgical Pathophysiology), SICE (Italian Society of Endoscopic Surgery and new technologies), and the WSES (World Society of Emergency Surgery) International Consensus Project.
Article in World journal of emergency surgery : WJES, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Optimal interventions for low anterior resection syndrome: Bayesian network meta-analysis of randomized controlled trials.Techniques in coloproctology · 2025Pooled it
- Preoperative chemoradiotherapy in older patients with rectal cancer guided by comprehensive geriatric assessment within a multidisciplinary team-a multicenter phase II trial.BMC geriatrics · 2024Trial
- Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision.The lancet. Healthy longevity · 2022Trial
- Outcomes of Elderly Patients with Colorectal Liver Metastases Treated with Liver-Directed Therapies.Annals of surgical oncology · 2026Article
- Age disparity in robotic colorectal surgery: overcoming surgeon hesitancy to improve elderly patient outcomes.Journal of robotic surgery · 2026Article
- Multidisciplinary Surgical Management of Radiation-Induced Colorectal Stricture and Pelvic Adhesions: A Case Report.Cureus · 2026Article
- Parenchymal-Sparing Strategy in Colorectal Liver Metastases: A Single-Center Experience.Current oncology (Toronto, Ont.) · 2026Article
- Emergency colorectal cancer in old and very elderly patients: a narrative review.Frontiers in oncology · 2026Review
- Retrospective analysis of curative rectal cancer surgery outcomes in elderly patients.Scientific reports · 2025Article
- Geriatric Approaches to Rectal Cancer: Moving Towards a Patient-Tailored Treatment Era.Journal of clinical medicine · 2025Review
- Association between 5-item modified frailty index and clinical outcomes in elderly rectal cancer patients after radical surgery.Scientific reports · 2025Article
- A machine learning-based model for predicting survival in patients with Rectosigmoid Cancer.PloS one · 2025Article
- Surgical Emergencies in Rectal Cancer: A Narrative Review.Journal of clinical medicine · 2024Review
- Review
- Assessing neoadjuvant therapy recommendations in 19 national and international guidelines for rectal cancer.Techniques in coloproctology · 2024Review
- Risk of Secondary Malignancies After Pelvic Radiation: A Population-based Analysis.European urology open science · 2024Article
- Elderly Rectal Cancer: An Updated Review.Current oncology reports · 2024Review
- Comprehensive geriatric assessment guided radiotherapy in elderly patients with locally advanced rectal cancer-exploratory results on nonoperative cohort of a multicenter prospective study.Therapeutic advances in medical oncology · 2024Article
- Age-related differences in progression patterns, follow-up strategies, and postoperative outcomes in locally advanced rectal cancer: insights from a large-scale validated study.Therapeutic advances in medical oncology · 2024Article
- Predictive value of frailty assessment tools in patients undergoing surgery for gastrointestinal cancer: An observational cohort study.World journal of gastrointestinal surgery · 2023Article
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Authors and funding
48 authors at 20 institutions in 10 countries.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAlthough rectal cancer is predominantly a disease of older patients, current guidelines do not incorporate optimal treatment recommendations for the elderly and address only partially the associated specific challenges encountered in this population. This results in a wide variation and disparity in delivering a standard of care to this subset of patients. As the burden of rectal cancer in the elderly population continues to increase, it is crucial to assess whether current recommendations on treatment strategies for the general population can be adopted for the older adults, with the same beneficial oncological and functional outcomes. This multidisciplinary experts' consensus aims to refine current rectal cancer-specific guidelines for the elderly population in order to help to maximize rectal cancer therapeutic strategies while minimizing adverse impacts on functional outcomes and quality of life for these patients.
methodsThe discussion among the steering group of clinical experts and methodologists from the societies' expert panel involved clinicians practicing in general surgery, colorectal surgery, surgical oncology, geriatric oncology, geriatrics, gastroenterologists, radiologists, oncologists, radiation oncologists, and endoscopists. Research topics and questions were formulated, revised, and unanimously approved by all experts in two subsequent modified Delphi rounds in December 2020-January 2021. The steering committee was divided into nine teams following the main research field of members. Each conducted their literature search and drafted statements and recommendations on their research question. Literature search has been updated up to 2020 and statements and recommendations have been developed according to the GRADE methodology. A modified Delphi methodology was implemented to reach agreement among the experts on all statements and recommendations.
conclusionsThe 2021 SICG-SIFIPAC-SICE-WSES consensus for the multidisciplinary management of elderly patients with rectal cancer aims to provide updated evidence-based statements and recommendations on each of the following topics: epidemiology, pre-intervention strategies, diagnosis and staging, neoadjuvant chemoradiation, surgery, watch and wait strategy, adjuvant chemotherapy, synchronous liver metastases, and emergency presentation of rectal cancer.
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