Evidence map›Paper›PMID 34215270›Full record

ReviewMalaria journal2021

The lead-up to epidemic transmission: malaria trends and control interventions in Burundi 2000 to 2019.

Denis Sinzinkayo, Dismas Baza, Virgile Gnanguenon, Cristian Koepfli

Open access · goldAbstract readReview
In one paragraph

Review in Malaria journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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  5. A NovelmedRxiv : the preprint server for health sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Denis SinzinkayoUniversity of Burundi, Bujumbura, Burundi.
Dismas BazaWorld Health Organization, Burundi Country Office, Bujumbura, Burundi.
Virgile GnanguenonPMI VectorLink Project, U.S. Agency for International Development, Abt Associates, Bujumbura, Burundi.
Cristian KoepfliUniversity of Notre Dame, Notre Dame, IN, USA. ckoepfli@nd.edu.ORCID http://orcid.org/0000-0002-9354-0414
International Institute of Tropical Agriculture · BIRepublic of Burundi · BIUniversité du Burundi · BIUniversity of Notre Dame · US

Funding

A Novel Droplet Digital PCR Method for Population-based Plasmodium falciparum hrp2 Deletion DiagnosisR21AI137891 · NIAID · UNIVERSITY OF NOTRE DAME · PI KOEPFLI, CRISTIAN · 2018 to 2019
$425k
National Institute of Allergy and Infectious Diseases R21AI137891NIAID NIH HHS R21 AI137891World Health Organization 001
6 · The paper itself

Abstract

Burundi has experienced an increase in malaria cases since 2000, reaching 843,000 cases per million inhabitants in 2019, a more than twofold increase compared to the early 2000s. Burundi thus contrasts the decreasing number of cases in many other African countries. To evaluate the impact of malaria control on this increase, data on interventions from 2000 to 2019 were compiled. Over this period, the number of health facilities increased threefold, and the number of tests 20-fold. The test positivity rate remained stable at around 50-60% in most years. Artemisinin-based combination therapy was introduced in 2003, initially using artesunate-amodiaquine and changed to artemether-lumefantrine in 2019/2020. Mass distribution campaigns of insecticide-treated bed nets were conducted, and indoor residual spraying and intermittent preventive treatment in pregnancy introduced. Thus, the increase in cases was not the result of faltering control activities. Increased testing was likely a key contributor to higher case numbers. Despite the increase in testing, the test positivity rate remined high, indicating that current case numbers might still underestimate the true burden.

Indexed as

AntimalarialsBurundiHumansInsecticide-Treated BednetsMalaria, FalciparumAntimalarialsEpidemicInterventionMalaria controlOutbreak

Identifiers

PMID34215270
PMCPMC8249825
OpenAlexW3174008638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.