Evidence map›Paper›PMID 34215215›Full record

ArticleBMC infectious diseases2021

Significant decline of HPV 6 infection and genital warts despite low HPV vaccination coverage in young women in Germany: a long-term prospective, cohort data analysis.

Agnieszka Denecke, Thomas Iftner, Angelika Iftner, Sebastian Riedle, Marion Ocak, Alexander Luyten, Isak Üye, Kübra Tunc, Karl Ulrich Petry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. [Anogenital warts-An update].Dermatologie (Heidelberg, Germany) · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Agnieszka DeneckeDepartment of Obstetrics and Gynecology, Klinikum Wolfsburg, Wolfsburg, Germany. agnieszka.denecke@klinikum.wolfsburg.de.ORCID http://orcid.org/0000-0003-1648-4452
Thomas IftnerInstitute of Medical Virology, University of Tübingen, Tübingen, Germany.
Angelika IftnerInstitute of Medical Virology, University of Tübingen, Tübingen, Germany.
Sebastian RiedleMD research, Statistics in clinical research, Pullach i, Isartal, Germany.
Marion OcakMD research, Statistics in clinical research, Pullach i, Isartal, Germany.
Alexander LuytenAbts+partner, Frauenärzte, Prüner Gang, Kiel, Germany.
Isak ÜyeDepartment of Obstetrics and Gynecology, Klinikum Wolfsburg, Wolfsburg, Germany.
Kübra TuncDepartment of Obstetrics and Gynecology, Klinikum Wolfsburg, Wolfsburg, Germany.
Karl Ulrich PetryDepartment of Obstetrics and Gynecology, Klinikum Wolfsburg, Wolfsburg, Germany.
Fraunhofer Project Centre Wolfsburg · DEUniversity of Tübingen · DEBerufsverband der Frauenärzte · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe introduction of human papillomavirus (HPV) vaccination has resulted in a remarkable decline of genital warts in women and men, but in Germany historical rates of vaccination are relatively low. We report long-term surveillance data on changes in HPV 6 and HPV 11 infection and the prevalence of genital warts in young women in the Wolfsburg HPV epidemiological study (WOLVES).

methodsWomen born in 1983/84, 1988/89, and 1993/94 participated in four cohorts between 2009/10 and 2014/15. Quadrivalent vaccination coverage and prevalence of HPV 6/11 infection and genital warts are reported for participants aged 19-22 years and 24-27 years at the time of sample collection. Statistical analyses were done to compare similarly aged participants using 2 × 2 contingency tables (Röhmel-Mansmann unconditional exact test; two-side alpha of 0.05).

resultsA total of 2456 women were recruited. Between 2010 and 2015, there was a statistically significant decrease in the prevalence of HPV 6 infection among women aged 24-27 years (2.1% versus 0.0%; P < 0.0001) and women aged 19-22 years (2.0% versus 0.0%; P = 0.0056). There was no significant decline in HPV 11 infection. In total, 52 of 2341 participants were diagnosed with genital warts. There was a statistically significant drop in the risk of developing genital warts in women aged 24-27 years between 2010 and 2015 (4.7% versus 1.7%, respectively; P = 0.0018). The overall risk of developing genital warts in women aged 19-27 years decreased from 3.1% in 2010 to 1.2% in 2015 (P = 0.0022).

conclusionsAn increase in vaccination coverage was associated with a decreased prevalence of genital warts in young women. A protective effect greater than herd immunity alone was seen despite low vaccination rates. Quadrivalent vaccine had a protective effect on genital HPV 6 infection and an almost fully protective effect on the development of genital warts in the youngest population.

Indexed as

AdolescentAdultCondylomata AcuminataFemaleGermanyHumansMalePapillomaviridaePapillomavirus InfectionsPapillomavirus VaccinesPrevalenceProspective StudiesVaccinationVaccination CoverageYoung AdultPapillomavirus VaccinesCondylomata acuminataGenital wartsHPV-vaccinationHuman papillomavirus

Identifiers

PMID34215215
PMCPMC8252220
OpenAlexW3173286503

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.