Trial reportNeuroImage. Clinical2021
Diminished prefrontal cortex activation in patients with binge eating disorder associates with trait impulsivity and improves after impulsivity-focused treatment based on a randomized controlled IMPULS trial.
Trial report in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Behavioural biases in the interaction with food objects in virtual reality and its clinical implication for binge eating disorder.Eating and weight disorders : EWD · 2023Trial
- Shared Brain factors in eating disorders and obesity: a systematic review of functional near-infrared spectroscopy (fNIRS) studies.Reviews in endocrine & metabolic disorders · 2026Review
- Effects of a single dose of psilocybin on diet-induced weight loss in obese mice.Translational psychiatry · 2026Article
- Intermittent theta burst stimulation (iTBS) and inhibitory control training to reduce binge eating: study protocol for a randomized controlled trial (Be-Nemoic).Frontiers in psychology · 2026Article
- Prefrontal Cortex Recruitment to Food Stimuli Differs in Overweight/Obesity and Binge Eating Disorder.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Graze Eating and Obesity: A Conceptualization Within the Spectrum of Disordered Eating.Current obesity reports · 2025Review
- Affective factors predicting Binge Eating Disorder: The role of emotion regulation, impulsivity, and cognitive distortions.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2025Article
- Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell.Neuroscience bulletin · 2024Article
- Reward and Inhibitory Control as Mechanisms and Treatment Targets for Binge Eating Disorder.Current psychiatry reports · 2024Review
- Article
- Neuromodulation of Eating Disorders: A Review of Underlying Neural Network Activity and Neuromodulatory Treatments.Brain sciences · 2024Review
- Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change.Neural plasticity · 2024Review
- Near-Infrared Spectroscopy: A Free-Living Neuroscience Tool to Better Understand Diabetes and Obesity.Metabolites · 2023Review
- Central Regulation of Eating Behaviors in Humans: Evidence from Functional Neuroimaging Studies.Nutrients · 2023Review
- Transdiagnostic Study of Impulsivity and Self-Injurious Behaviour in Unstable and Impulsive Disorders.Actas espanolas de psiquiatria · 2023Article
- Binge eating, depressive symptoms and suicidal ideation in obese candidates for bariatric surgery.Eating and weight disorders : EWD · 2023Article
- The effect of hunger state on hypothalamic functional connectivity in response to food cues.Human brain mapping · 2023Article
- Neurofeedback strategies in binge-eating disorder as predictors of EEG-neurofeedback regulation success.Frontiers in human neuroscience · 2023Article
- The relationships between social media exposure, food craving, cognitive impulsivity and cognitive restraint.Journal of eating disorders · 2022Article
- Neurobiological regulation of eating behavior: Evidence based on non-invasive brain stimulation.Reviews in endocrine & metabolic disorders · 2022Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBehavioral and cognitive control are vital for healthy eating behavior. Patients with binge eating disorder (BED) suffer under recurrent binge eating episodes accompanied by subjective loss of control that results, among other factors, from increased impulsivity.
methodsIn the current study, we investigated the frontal network using functional near-infrared spectroscopy (fNIRS) during a food specific go/nogo task to assess response inhibition in 24 patients with BED (BMI range 22.6-59.7 kg/m
resultsWe found a significant response inhibition effect (nogo minus go), in terms of an increased oxygenated hemoglobin response in the bilateral prefrontal cortex in both groups. The greatest response was observed when participants were instructed to go for healthy and withhold their response to unhealthy high caloric food cues. The healthy nogo condition failed to show a significant prefrontal inhibitory response, which was probably related to the task design, as the condition was considered more demanding. BED patients, especially those with higher trait impulsivity, showed a weaker activation of the prefrontal cortex during response inhibition, predominantly in the right hemisphere. Interestingly, three months after the treatment, patients of the treatment group increased their right prefrontal cortex activity during response inhibition. Likewise, increased prefrontal cortex activation correlated with decreased trait impulsivity after treatment.
conclusionsOur results suggest that patients with BED have limited resources to activate the prefrontal cortex when asked to inhibit a reaction onto food-specific stimuli. However, this effect could be partly driven by differences in BMI between the HC and BED group. Cognitive-behavioral therapy targeting impulsive eating behavior may improve prefrontal cortex recruitment during response inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.