Evidence map›Paper›PMID 34215140›Full record

ArticleNeuroImage. Clinical2021

Neural basis of working memory in ADHD: Load versus complexity.

Prerona Mukherjee, Tadeus Hartanto, Ana-Maria Iosif, J Faye Dixon, Stephen P Hinshaw, Murat Pakyurek, Wouter van den Bos, Amanda E Guyer, Samuel M McClure, Julie B Schweitzer and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Prerona MukherjeeDepartment of Psychiatry and Behavioral Sciences and MIND Institute, University of California, Davis, 2825 50th St., Sacramento, CA 95817, USA. Electronic address: pmukherjee@ucdavis.edu.
Tadeus HartantoDepartment of Psychiatry and Behavioral Sciences and MIND Institute, University of California, Davis, 2825 50th St., Sacramento, CA 95817, USA.
Ana-Maria IosifDepartment of Public Health Sciences, University of California, Davis, Davis, CA 95616, USA.
J Faye DixonDepartment of Psychiatry and Behavioral Sciences and MIND Institute, University of California, Davis, 2825 50th St., Sacramento, CA 95817, USA.
Stephen P HinshawDepartment of Psychology, University of California, Berkeley, 3rd Floor, Berkeley Way West Building, 2121 Berkeley Way West, Berkeley, CA 94720, USA.
Murat PakyurekDepartment of Psychiatry and Behavioral Sciences and MIND Institute, University of California, Davis, 2825 50th St., Sacramento, CA 95817, USA.
Wouter van den BosDepartment of Developmental Psychology, University of Amsterdam, Nieuwe Achtergracht 129-B, 1018 WS Amsterdam, Netherlands.
Amanda E GuyerDepartment of Human Ecology, University of California, Davis, 1 Shields Ave, Davis, CA 95616, USA; Center for Mind and Brain, University of California, Davis, 267 Cousteau Pl, Davis, CA 95618, USA.
Samuel M McClureDepartment of Psychology, Arizona State University, Tempe, AZ 85287, USA.
Julie B SchweitzerDepartment of Psychiatry and Behavioral Sciences and MIND Institute, University of California, Davis, 2825 50th St., Sacramento, CA 95817, USA.
Catherine FassbenderDepartment of Psychiatry and Behavioral Sciences and MIND Institute, University of California, Davis, 2825 50th St., Sacramento, CA 95817, USA; School of Psychology, Dublin City University, DCU Glasnevin Campus, Dublin 9, Ireland.
University of California, Davis · USArizona State University · USDublin City University · IEUniversity of Amsterdam · NLUniversity of California, Berkeley · US

Funding

Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2019
$8.5M
Developmental Changes in Neural Processes Underlying Inattention, Impulsivity and RegulationR01MH091068 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHWEITZER, JULIE B. · 2012 to 2022
$7.4M
NICHD NIH HHS U54 HD079125NIMH NIH HHS R01 MH091068
6 · The paper itself

Abstract

Working memory (WM) deficits are key in attention deficit hyperactivity disorder (ADHD). Nevertheless, WM is not universally impaired in ADHD. Additionally, the neural basis for WM deficits in ADHD has not been conclusively established, with regions including the prefrontal cortex, cerebellum, and caudate being implicated. These contradictions may be related to conceptualizations of WM capacity, such as load (amount of information) versus operational-complexity (maintenance-recall or manipulation). For instance, relative to neurotypical (NT) individuals, complex WM operations could be impaired in ADHD, while simpler operations are spared. Alternatively, all operations may be impaired at higher loads. Here, we compared the impact of these two components of WM capacity: load and operational-complexity, between ADHD and NT, behaviorally and neurally. We hypothesized that the impact of WM load would be greater in ADHD, and the neural activation would be altered. Participants (age-range 12-23 years; 50 ADHD (18 females); 82 NT (41 females)) recalled three or four objects (load) in forward or backward order (operational-complexity) during functional magnetic resonance imaging scanning. The effects of diagnosis and task were compared on performance and neural engagement. Behaviorally, we found significant interactions between diagnosis and load, and between diagnosis, load, and complexity. Neurally, we found an interaction between diagnosis and load in the right striatum, and between diagnosis and complexity in the right cerebellum and left occipital gyrus. The ADHD group displayed hypo-activation compared to NT group during higher load and greater complexity. This informs mechanisms of functional problems related to WM in adolescents and young adults with ADHD (e.g., academic performance) and remedial interventions (e.g., WM-training).

Indexed as

Attention Deficit Disorder with HyperactivityAdolescentAdultChildFemaleHumansMagnetic Resonance ImagingMemory, Short-TermMental RecallPrefrontal CortexYoung AdultADHDCaudateCerebellumfMRIFunctional imagingPrefrontal cortexWorking memory capacity

Identifiers

PMID34215140
PMCPMC8175567
OpenAlexW3141438040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.