ArticleBiomaterials2021
Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery.
Article in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 88 citations in OpenAlex.
- Long-term exploratory evaluation of an acellular biomimetic polyfascicular nerve guidance conduit for peripheral nerve repair in a rhesus macaque model.Bioactive materials · 2027Article
- Stimulation Based Drug Release From Dual-Layered Microspheres.Macromolecular bioscience · 2026Article
- Collagen IV outperforms alternative ECM coatings to preserve human neural progenitor properties on electrically conductive neural interfaces.Scientific reports · 2026Article
- Integrating Cells, Biomaterials, and Advanced Engineering for Next-Generation Peripheral Nerve Repair.Cells, tissues, organs · 2026Review
- Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell-Mediated Repair Traumatic Brain Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advanced multifunctional thermo- and electro-stimulative hydrogels for bone regeneration.Materials today. Bio · 2026Review
- Review
- Acutely denervated muscle EVs reshape neuronal mitochondrial metabolism via retrograde signaling to rescue peripheral nerve injury.Cell reports. Medicine · 2026Article
- Functional and Morphological Outcomes of Duration-Dependent Electrical Stimulation in Silicone Conduit-Mediated Peripheral Nerve Repair in Rats.Bioengineering (Basel, Switzerland) · 2026Article
- Biocompatible, Ion-Conductive Hydrogel-Filled Nerve Conduit for Peripheral Nerve Regeneration.ACS applied materials & interfaces · 2026Article
- Engineering 3D-printed standalone conductive nerve guides using soft bioinks for peripheral nerve injuries.Materials advances · 2026Article
- Electrical Stimulation and Platelet-Rich Plasma as Complementary Approaches for Peripheral Nerve Regeneration.Cellular and molecular neurobiology · 2025Review
- Mapping the research landscape of nanotechnology based immunotherapy for hepatocellular carcinoma.Discover oncology · 2025Article
- Multidimensional advances in neural interface technology for peripheral nerve repair: From material innovation to clinical translation.Materials today. Bio · 2025Review
- 3D-Printing of Electroconductive MXene-Based Micro-Meshes in a Biomimetic Hyaluronic Acid-Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advances in sciatic nerve regeneration: A review of contemporary techniques.Regenerative therapy · 2025Review
- Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair.Bioactive materials · 2025Article
- Network Medicine as a Tool to Enhance Regenerative Rehabilitation Practice.American journal of physical medicine & rehabilitation · 2025Article
- Biocompatible EDOT-Pyrrole Conjugated Conductive Polymer Coating for Augmenting Cell Attachment, Activity, and Differentiation.ACS applied bio materials · 2025Article
- From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair.Materials today. Bio · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Severe peripheral nerve injuries often result in permanent loss of function of the affected limb. Current treatments are limited by their efficacy in supporting nerve regeneration and behavioral recovery. Here we demonstrate that electrical stimulation through conductive nerve guides (CNGs) enhances the efficacy of human neural progenitor cells (hNPCs) in treating a sciatic nerve transection in rats. Electrical stimulation strengthened the therapeutic potential of NPCs by upregulating gene expression of neurotrophic factors which are critical in augmenting synaptic remodeling, nerve regeneration, and myelination. Electrically-stimulated hNPC-containing CNGs are significantly more effective in improving sensory and motor functions starting at 1-2 weeks after treatment than either treatment alone. Electrophysiology and muscle assessment demonstrated successful re-innervation of the affected target muscles in this group. Furthermore, histological analysis highlighted an increased number of regenerated nerve fibers with thicker myelination in electrically-stimulated hNPC-containing CNGs. The elevated expression of tyrosine kinase receptors (Trk) receptors, known to bind to neurotrophic factors, indicated the long-lasting effect from electrical stimulation on nerve regeneration and distal nerve re-innervation. These data suggest that electrically-enhanced stem cell-based therapy provides a regenerative rehabilitative approach to promote peripheral nerve regeneration and functional recovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.