Evidence map›Paper›PMID 34214731›Full record

ArticleClinical biomechanics (Bristol, Avon)2021

Potential effect of pulmonary fluid viscosity on positive end-expiratory pressure and regional distribution of lung ventilation in acute respiratory distress syndrome.

Zhenglong Chen, Zhaoyan Hu, Ming Zhong, Linhong Deng, Jiale Tao, Yuanlin Song

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Zhenglong ChenSchool of Medical Instrumentation, Shanghai University of Medicine & Health Sciences, Shanghai, China; NMPA Key Laboratory for Respiratory and Anaesthetic Equipment, Shanghai, China.
Zhaoyan HuSchool of Medical Instrumentation, Shanghai University of Medicine & Health Sciences, Shanghai, China; NMPA Key Laboratory for Respiratory and Anaesthetic Equipment, Shanghai, China.
Ming ZhongDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: zhong_ming@fudan.edu.cn.
Linhong DengInstitute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, China.
Jiale TaoDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yuanlin SongDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: ylsong70@163.com.
Shanghai University of Medicine and Health Sciences · CNSun Yat-sen University · CNChangzhou University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComputational fluid dynamic simulations have showed that the elevated viscosity of pulmonary fluids may increase the likelihood of airway closure, thus exacerbating inhomogeneity of regional lung ventilation. Unfortunately, there have been few studies directed toward measurements of viscosity of pulmonary fluids and its effect on airway opening pressure and regional distribution of lung ventilation in acute respiratory distress syndrome.

methodsIn this study, pulmonary fluids from 8 ARDS patients were measured using a cone and plate rheometer on days 1, 3, 7 and 14 in the treatment of the disorder. Ventilator settings were simultaneously recorded, including tidal volume, positive end-expiratory pressure, fraction of inspired oxygen (FiO

findingsThe results showed that rheological properties of pulmonary fluids behaved as either Newtonian or non-Newtonian across all patients studied. Significant intersubject and intrasubject variations in measured viscosities were observed, spanning ranges from approximately 1 cP to 7 × 10

interpretationThe current findings provided the direct clinical data for theoretical models of airway reopening and may have important clinical implications in explaining inhomogeneity of lung ventilation and selecting initial levels of positive end-expiratory pressure in mechanically ventilated patients.

Indexed as

Respiratory Distress SyndromeHumansLungPositive-Pressure RespirationRespiration, ArtificialViscosityAcute respiratory distress syndromeAirway opening pressureLung mechanicsPulmonary fluidViscosity

Identifiers

PMID34214731
PMCPMC9756214
OpenAlexW3172375699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.