Evidence map›Paper›PMID 34214707›Full record

ArticleCellular and molecular gastroenterology and hepatology2021

Prebiotic Enriched Exclusive Enteral Nutrition Suppresses Colitis via Gut Microbiome Modulation and Expansion of Anti-inflammatory T Cells in a Mouse Model of Colitis.

Genelle R Lunken, Kevin Tsai, Alana Schick, Daniel J Lisko, Laura Cook, Bruce A Vallance, Kevan Jacobson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Current research in food science · 2025
    Article
  8. Article
  9. Review
  10. An Inulin-Type Fructan CP-A fromPharmaceuticals (Basel, Switzerland) · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Observational
  19. Frontiers in veterinary science · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Genelle R LunkenBC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Gut4Health Microbiome Core Facility, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.
Kevin TsaiBC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Alana SchickBC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Gut4Health Microbiome Core Facility, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.
Daniel J LiskoBC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Laura CookBC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Bruce A VallanceBC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Gut4Health Microbiome Core Facility, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada; Division of Gastroenterology, Hepatology and Nutrition, BC Children's Hospital, Vancouver, Canada. Electronic address: bvallance@cw.bc.ca.
Kevan JacobsonBC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Division of Gastroenterology, Hepatology and Nutrition, BC Children's Hospital, Vancouver, Canada. Electronic address: kjacobson@cw.bc.ca.
University of British Columbia · CA

Funding

CIHR 159528CIHR PJT-148846
6 · The paper itself

Abstract

BACKGROUND &

aimsExclusive enteral nutrition (EEN) is used to treat pediatric Crohn's disease (CD), but therapeutic benefits are variable, and EEN can lead to microbial dysbiosis. Because of reported lower efficacy EEN is not routinely used to treat pediatric ulcerative colitis (UC). Inulin-type fructans (IN) beneficially modulate the gut microbiome and promote expansion of anti-inflammatory immune cells. We hypothesized that enriching EEN with IN (EEN IN) would enhance treatment efficacy. To test this, we examined the effects of EEN IN on colitis development, the gut microbiome, and CD4

methodsTCR-β deficient (

resultsMice fed EEN IN showed greater colitis protection, with colonic shortening, goblet cell, and crypt density loss reduced compared with EEN fed mice and reduced disease activity and immune cell infiltration compared with chow fed mice, and less crypt hyperplasia and higher survival compared with both groups. EEN IN mice had less deterioration in the colonic mucus layer and had increased levels of Foxp3

conclusionsThe EEN IN group showed reduced colitis development as compared with the chow and EEN groups. This highlights the potential benefits of EEN IN as a novel induction therapy for pediatric CD and UC patients.

Indexed as

Enteral NutritionGastrointestinal MicrobiomePrebioticsAnimalsBiomarkersColitisDisease Models, AnimalDisease SusceptibilityForkhead Transcription FactorsImmunomodulationMiceMice, KnockoutPhenotypeT-LymphocytesBiomarkersForkhead Transcription FactorsFoxp3 protein, mousePrebioticsInflammatory Bowel DiseaseMicrobiomePrebioticRegulatory T Cells

Identifiers

PMID34214707
PMCPMC8453203
OpenAlexW3176533716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.