ArticleThe American journal of pathology2021
Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy.
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Article in The American journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 25% of its field
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Calpain Inhibitors as Potential Therapeutic Modulators in Neurodegenerative Diseases.Neurochemical research · 2022Pooled it
- L-DOPA Promotes Post-Treatment Neurovascular and Synaptic Homeostasis in Early Diabetic Retinopathy.Investigative ophthalmology & visual science · 2026Article
- Calcium at the Helm: Mechanisms and Therapeutic Targets in the Retinal Neurovascular Unit.Biomolecules · 2026Review
- Explaining Retinal Susceptibility to Diabetes Through Photoreceptor Biology.International journal of molecular sciences · 2026Review
- L-DOPA treatment promotes sustained neurovascular and synaptic homeostasis in the diabetic retina.bioRxiv : the preprint server for biology · 2026Article
- WWOX Induction Promotes Bcl-XCells · 2026Article
- Article
- Alterations of Photoreceptor Synaptic Ribbons in the Retina of a Human Patient With Oculocutaneous Albinism Type 1 (OCA1).Investigative ophthalmology & visual science · 2025Article
- CYBB identified as a key immune hub gene linking lung cancer and atrial fibrillation.Journal of cardiothoracic surgery · 2025Article
- The Exploration of Disturbance of Capillary and Photoreceptor Communication Networks in Diabetic Retinopathy Through Single-Cell RNA-Seq.Journal of cellular and molecular medicine · 2025Article
- System biology analysis reveals that Grm6 is associated with glutamate accumulation-induced scotopic vision impairment in diabetic mice.Molecular vision · 2025Article
- Microglia response and function in a chronic model of photoreceptor damage.Frontiers in cell and developmental biology · 2025Article
- Article
- Zfra Overrides WWOX in Suppressing the Progression of Neurodegeneration.International journal of molecular sciences · 2024Review
- Increasing Energetic Demands on Photoreceptors in Diabetes Corrects Retinal Lipid Dysmetabolism and Reduces Subsequent Microvascular Damage.The American journal of pathology · 2023Article
- A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish.Frontiers in cell and developmental biology · 2023Article
- Calpains as mechanistic drivers and therapeutic targets for ocular disease.Trends in molecular medicine · 2022Review
- Carvacrol protects the ARPE19 retinal pigment epithelial cells against high glucose-induced oxidative stress, apoptosis, and inflammation by suppressing the TRPM2 channel signaling pathways.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- MicroRNA-150 and its target ETS-domain transcription factor 1 contribute to inflammation in diabetic photoreceptors.Journal of cellular and molecular medicine · 2021Article
- A Novel Tree Shrew Model of Diabetic Retinopathy.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Aicha SaadaneDepartment of Ophthalmology, University of California, Irvine, Irvine, California. Electronic address: asaadane@hs.uci.edu.
Yunpeng DuDepartment of Ophthalmology, University of California, Irvine, Irvine, California.
Wallace B ThoresonDepartment of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska.
Masaru MiyagiDepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio.
Emma M LessieurDepartment of Ophthalmology, University of California, Irvine, Irvine, California.
Jianying KiserDepartment of Ophthalmology, University of California, Irvine, Irvine, California.
Xiangyi WenDepartment of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska.
Bruce A BerkowitzDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan.
Timothy S KernDepartment of Ophthalmology, University of California, Irvine, Irvine, California; Veterans Administration Medical Center Research Service, Long Beach, California.
University of California, Irvine · USCase Western Reserve University · USNebraska Medical Center · USUnited States Department of Veterans Affairs · USUniversity of Nebraska Medical Center · USWayne State University · US
Funding
TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7MVISION RESEARCH--COREP30EY004068 · NEI · WAYNE STATE UNIVERSITY · PI LINDA D HAZLETT · 1985 to 2026
$13.2MNovel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1MRegulation of Photoreceptor NeurotransmisssionR01EY010542 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KARATEKIN, ERDEM, THORESON, WALLACE B · 2001 to 2023
$7.7MRole of Photoreceptors in the Pathogenesis of Diabetic RetinopathyR01EY022938 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2013 to 2021
$3.7MNovel Imaging Biomarker for Treating Spatial Memory Loss in Prodromal Alzheimer's Disease ModelsR01AG058171 · NIA · WAYNE STATE UNIVERSITY · PI BENNETT, BRIAN M, BERKOWITZ, BRUCE A. · 2017 to 2021
$2.8MNovel Imaging of rod oxidative stress in retinal disease and treatment in vivoR01EY026584 · NEI · WAYNE STATE UNIVERSITY · PI BERKOWITZ, BRUCE A. · 2016 to 2019
$1.5MCHLORIDE REGULATION OF PHOTORECEPTOR NEUROTRANSMISSIONR29EY010542 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THORESON, WALLACE B · 1996 to 2000
$105kBLR&D Research Career Scientist ApplicationIK6BX003604 · VA · VETERANS HEALTH ADMINISTRATION · PI KERN, TIMOTHY S · 2017 to 2021
–BLRD VA IK6 BX003604NEI NIH HHS P30 EY004068NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY010542NEI NIH HHS R01 EY022938NEI NIH HHS R01 EY026584NEI NIH HHS R24 EY024864NEI NIH HHS R29 EY010542NIA NIH HHS R01 AG058171
Abstract
This study tested the hypothesis that diabetes promotes a greater than normal cytosolic calcium level in rod cells that activates a Ca
Indexed as
Oxidative StressAnimalsCalciumCalpainCell LineDiabetic RetinopathyEnzyme ActivationGene DeletionGene Expression RegulationGlycoproteinsInflammationIntercellular Adhesion Molecule-1MiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IICalciumCalpaincalpain inhibitorsGlycoproteinsIntercellular Adhesion Molecule-1Nitric Oxide Synthase Type IIProteomeSuperoxidesWW Domain-Containing OxidoreductaseWwox protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.