ArticleCell2021
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
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In one paragraph
Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Monogenic etiologies of persistent human papillomavirus infections: A comprehensive systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2024Pooled it
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Allogeneic hematopoietic cell transplantation is curative in CARMIL2 deficiency.Journal of human immunity · 2026Article
- Primary atopic disorders: Monogenic insights into immunity.Journal of human immunity · 2026Review
- A Flow Cytometry-Based Assay to Quantify the Binding of Transmembrane Ligands to Their Cognate Receptors Using Fluorescent Virus-Like Particles.Bio-protocol · 2026Article
- A flow cytometry-based assay to quantify the binding of transmembrane ligands to their cognate receptors using fluorescent virus-like particles.bioRxiv : the preprint server for biology · 2026Article
- The human skin virome: Ecological dynamics, aberrant profiles, and therapeutic opportunities.Cell host & microbe · 2026Review
- Toward a monogenic architecture of human infections: From 1996 to 2026.Journal of human immunity · 2026Review
- Cell-Mediated Immunity Against Human Papillomavirus Infection: From Viral Clearance to Oncogenesis.Viruses · 2026Review
- CD28-deficient mice are vulnerable to mouse papillomavirus MmuPV1 infection of the skin and mucosae.PLoS pathogens · 2026Article
- Human LFA-1 governs T cell immune surveillance of the skin.Science immunology · 2026Article
- Nectin-4 reduces T cell effector function and is a therapeutic target in pancreatic cancer.JCI insight · 2026Article
- Associations of viral infections, including cutaneous warts, and sleep quality with immune function in treatment-naïve breast cancer patient: a cross-sectional study.Frontiers in medicine · 2026Article
- Interactions Between Immunosuppressive Regimens and Cytomegalovirus Infection After Solid-Organ Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- CTLA4 genetic variants influence immune regulation and susceptibility of HPV associated cervical cancer.Discover oncology · 2025Review
- Restoration of the human skin microbiome following immune recovery after hematopoietic stem cell transplantation.Cell host & microbe · 2025Article
- Human immunity to fungal infections.The Journal of experimental medicine · 2025Review
- Decoding Immunobiology Through Genetic Errors of Immunity.Annual review of immunology · 2025Review
- The monogenic landscape of human infectious diseases.The Journal of allergy and clinical immunology · 2025Review
- Opinion: the evolving understanding of polygenic common variable immunodeficiency-like disorders.Frontiers in immunology · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
74 authors at 20 institutions in 9 countries.
Vivien BéziatUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; The Rockefeller University, New York, NY 10065, USA. Electronic address: vivien.beziat@inserm.fr.
Franck RapaportThe Rockefeller University, New York, NY 10065, USA.
Jiafen HuPennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Matthias TiteuxUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
Mathilde Bonnet des ClaustresUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
Mathieu BourgeyMcGill University, Montreal, QC H3A 0G1, Canada.
Heather GriffinUniversity of Cambridge, Cambridge CB2 1QP, UK.
Élise BandetUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
Cindy S MaGarvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia.
Roya SherkatIsfahan University of Medical Sciences, AIRC, Isfahan 81746-73461, Iran.
Hassan Rokni-ZadehZanjan University of Medical Sciences, Zanjan 45139-56184, Iran.
David M LouisStanford University Medical School, Stanford, CA 94305, USA.
Majid Changi-AshtianiInstitute for Research in Fundamental Sciences (IPM), Tehran 19395-5746, Iran.
Ottavia M DelmonteNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Toshiaki FukushimaInstitute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Tanwir HabibSidra Medicine, Doha, Qatar.
Andrea GuennounSidra Medicine, Doha, Qatar.
Taushif KhanSidra Medicine, Doha, Qatar.
Noemi BenderGerman Cancer Research Center, 69120 Heidelberg, Germany.
Mahbuba RahmanSidra Medicine, Doha, Qatar.
Frédégonde AboutUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
Rui YangThe Rockefeller University, New York, NY 10065, USA.
Geetha RaoGarvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia.
Claire RouzaudUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Jingwei LiPennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Debra ShearerPennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Karla BaloghPennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Fatima Al AliSidra Medicine, Doha, Qatar.
Manar AtaSidra Medicine, Doha, Qatar.
Soroosh DabiriZahedan University of Medical Sciences, 054 Zahedan, Iran.
Mana MomenilandiUniversity of Leuven, 3000 Leuven, Belgium.
Justine NammourUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
Marie-Alexandra AlyanakianNecker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Marianne Leruez-VilleNecker Hospital for Sick Children, AP-HP, 75015 Paris, France.
David GuenatPapillomavirus National Reference Center, Besançon Hospital, 25030 Besançon, France.
Marie MaternaUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
Léa MarcotUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
Natasha VladikineUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
Christine SoretPapillomavirus National Reference Center, Besançon Hospital, 25030 Besançon, France.
Hassan VahidnezhadThomas Jefferson University, Philadelphia, PA 19107, USA.
Leila YoussefianThomas Jefferson University, Philadelphia, PA 19107, USA.
Amir Hossein SaeidianThomas Jefferson University, Philadelphia, PA 19107, USA.
Jouni UittoThomas Jefferson University, Philadelphia, PA 19107, USA.
Émilie CatherinotFoch Hospital, 92150 Suresnes, France.
Shadi Sadat NavabiDr. Shahrooei Lab, Ahvaz, Iran.
Mohammed ZarhrateUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
David T WoodleyUniversity of Southern California, Los Angeles, CA 90033, USA.
Mohamed JeljeliCochin University Hospital, AP-HP, 75014 Paris, France.
Thomas AbrahamPennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Serkan BelkayaThe Rockefeller University, New York, NY 10065, USA.
Lazaro LorenzoUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France.
Jérémie RosainUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Mousa BayatZahedan University of Medical Sciences, 054 Zahedan, Iran.
Fanny LanternierUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Olivier LortholaryUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Faramarz ZakaviAhvaz Jundishapur University of Medical Sciences, 061 Ahvaz, Iran.
Philippe GrosMcGill University, Montreal, QC H3A 0G1, Canada; McGill Research Centre on Complex Traits, Montreal, QC H3G 0B1, Canada.
Gérard OrthPasteur Institute, 75015 Paris, France.
Laurent AbelUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; The Rockefeller University, New York, NY 10065, USA.
Jean-Luc PrétetPapillomavirus National Reference Center, Besançon Hospital, 25030 Besançon, France.
Sylvie FraitagNecker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Emmanuelle JouanguyUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; The Rockefeller University, New York, NY 10065, USA.
Mark M DavisHHMI, Stanford University Medical School, Stanford, CA 94305, USA.
Stuart G TangyeGarvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia.
Luigi D NotarangeloNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Nico MarrSidra Medicine, Doha, Qatar.
Tim WaterboerGerman Cancer Research Center, 69120 Heidelberg, Germany.
David LanglaisMcGill University, Montreal, QC H3A 0G1, Canada; McGill Research Centre on Complex Traits, Montreal, QC H3G 0B1, Canada.
John DoorbarUniversity of Cambridge, Cambridge CB2 1QP, UK.
Alain HovnanianUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Neil ChristensenPennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Xavier BossuytUniversity of Leuven, 3000 Leuven, Belgium.
Mohammad ShahrooeiUniversity of Leuven, 3000 Leuven, Belgium; Dr. Shahrooei Lab, Ahvaz, Iran.
Jean-Laurent CasanovaUniversity of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; The Rockefeller University, New York, NY 10065, USA; HHMI, New York, NY 10065, USA. Electronic address: casanova@rockefeller.edu.
Inserm · FRPennsylvania State University · USUniversité Paris Cité · FRInstitut des Maladies Génétiques Imagine · FRThomas Jefferson University · USCentre Hospitalier Universitaire de Besançon · FRKU Leuven · BEMcGill University · CARockefeller University · USSt Vincent's Clinic · AUHôpital Necker-Enfants Malades · FRNational Institute of Allergy and Infectious Diseases · USStanford University · USUniversity of Cambridge · GBZahedan University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IRAssistance Publique – Hôpitaux de Paris · FRGerman Cancer Research Center · DEHeidelberg University · DEHôpital Cochin · FR
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MDeveloping, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MCharacterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MMolecular and cellular basis of epidermodysplasia verruciformisR01AI143810 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT, JOUANGUY, EMMANUELLE · 2020 to 2024
$2.0MCancer Research UK 28754Medical Research Council MC_PC_13050Medical Research Council MC_U117584278Medical Research Council MR/S024409/1NCATS NIH HHS UL1 TR001866NIAID NIH HHS R01 AI143810NIAID NIH HHS U19 AI057229
Abstract
We study a patient with the human papilloma virus (HPV)-2-driven "tree-man" phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4
Indexed as
AdultAmino Acid SequenceAnimalsBase SequenceCD28 AntigensCD4-Positive T-LymphocytesChildEndopeptidasesFemaleGenes, RecessiveHEK293 CellsHomozygoteHumansImmunity, HumoralImmunologic MemoryInheritance PatternsCD28 AntigensEndopeptidasesProtein Sorting SignalsRNA, MessengerUSP37 protein, humanCD28cutaneous hornHPVimmunodeficiencyoncogenepapillomavirussomatic reversionT celltree man syndromewart
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.