Evidence map›Paper›PMID 34214436›Full record

ArticleCell stem cell2021

Releasing the brake on protein synthesis in hematopoietic stem cells.

Craig M Forester, Davide Ruggero

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Craig M ForesterDepartment of Pediatrics, University of Colorado, Denver, CO, USA; Children's Hospital Colorado, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: craig.forester@cuanschutz.edu.
Davide RuggeroSchool of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA 94158, USA. Electronic address: davide.ruggero@ucsf.edu.
Children's Hospital Colorado · USUniversity of California, San Francisco · US

Funding

Research Training in Childhood CancerT32CA128583 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Alejandro Sweet-Cordero · 2007 to 2026
$6.0M
Profiling Translational Control of Gene Expression and Nascent Proteomic Responses in Erythropoietic Progression and RibosomopathiesK08DK119561 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI FORESTER, CRAIG M. · 2019 to 2022
$781k
NCI NIH HHS T32 CA128583NIDDK NIH HHS K08 DK119561
6 · The paper itself

Abstract

Protein synthesis regulation constitutes a key node in directing decisions between hematopoietic stemness and differentiation. In this issue of Cell Stem Cell, Lv et al. (2021) describe a mechanism by which HSCs fine-tune translation rates by controlling 60S and 40S ribosomal subunit joining through targeted degradation of ZNF622 in response to stress.

Indexed as

Hematopoietic Stem CellsCell Differentiation

Identifiers

PMID34214436
OpenAlexW3177132864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.