Evidence map›Paper›PMID 34214173›Full record

ArticleSleep2021

Racial disparities in sleep-related cardiac function in young, healthy adults: implications for cardiovascular-related health.

Janelle E Letzen, Mercedes L Robinson, Jared M Saletin, Rosanne B Sheinberg, Michael T Smith, Claudia M Campbell

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Janelle E LetzenDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Mercedes L RobinsonDepartment of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jared M SaletinDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.ORCID 0000-0002-8547-0161
Rosanne B SheinbergDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Michael T SmithDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Claudia M CampbellDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USBrown University · USUniversity of California, San Francisco · US

Funding

Effects of experimental sleep disruption and fragmentation on cerebral Mu-opioid receptor function, Mu-opioid receptor agonist analgesia, and abuse liability.U01HL150568 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SMITH, MICHAEL T · 2019 to 2024
$6.4M
Sleep Deprivation and Pain ModulationR21NS051771 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SMITH, MICHAEL T · 2004 to 2005
$380k
NHLBI NIH HHS U01 HL150568NINDS NIH HHS R21 NS051771
6 · The paper itself

Abstract

STUDY

objectivesConsiderable evidence shows that individuals from marginalized racial/ethnic groups in the United States experience greater rates of sleep disturbance and cardiovascular complications. Because sleep is a modifiable factor that is critically involved in cardiovascular health, improved understanding of the association between sleep and cardiovascular health during early adulthood can prevent cardiovascular disparities. This study examined racial/ethnic differences in cardiovascular function during sleep using heart rate and heart-rate-variability analyses.

methodsParticipants in this laboratory-based sleep study included healthy, "good sleepers" who were in early adulthood and resided in the United States at the time of participation (14 non-Hispanic Black [NHB; age = 30.9 (6.6), 57% female], 12 Asian [Asian, age = 26.0 (5.2), 42% female], and 24 non-Hispanic white [NHW; age = 24.6 (5.8), 79% female]).

resultsAfter adjusting for demographic factors and an apnea-hypopnea index, we found significantly higher heart rate within NREM Stage 2 (N2) (b = -22.6, p = .04) and REM sleep (b = -25.8, p =.048) and lower heart rate variability during N2 sleep (b = -22.6, p = .04) among NHB individuals compared with NHW individuals. Furthermore, NHB and Asian participants demonstrated significantly lower percent of time in slow wave sleep (SWS) compared with NHW participants (NHB: b = -22.6, p =.04; Asian: b = -22.6, p = .04). Individuals' percent of time in SWS significantly mediated differences in heart rate during N2 (indirect = 0.94, 95% CI [0.03, 2.68]) and REM sleep (indirect = 1.02, 95% CI [0.04, 3.04]).

conclusionsOur results showed disparities in sleep-related cardiovascular function in early adulthood that are mediated by SWS. These data suggest targeting sleep health in early adulthood might help reduce cardiovascular disease burden on individuals from marginalized groups.

Indexed as

Black or African AmericanWhite PeopleAdultEthnicityFemaleHealth Status DisparitiesHumansMaleRacial GroupsSleepUnited StatesYoung Adultcardiovascular healthheart rate variabilitysleep disparitiesSWS

Identifiers

PMID34214173
PMCPMC8598177
OpenAlexW3173613953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.