Evidence map›Paper›PMID 34214103›Full record

ArticlePloS one2021

The impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.

Kelly C Harper, Jean-Paul Salameh, Natasha Akhlaq, Matthew D F McInnes, Victoria Ivankovic, Mahdi H Beydoun, Edward G Clark, Wanzhen Zeng, Brian D M Blew, Kevin D Burns and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Kelly C HarperDepartment of Radiology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Jean-Paul SalamehOttawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Ontario, Canada.
Natasha AkhlaqDepartment of Radiology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Matthew D F McInnesDepartment of Radiology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Victoria IvankovicFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Mahdi H BeydounFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Edward G ClarkDivision of Nephrology, Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Wanzhen ZengDivision of Nuclear Medicine, Department of Medicine, University of Ottawa, The Ottawa Hospital, Ottawa, Ontario, Canada.
Brian D M BlewDivision of Urology, Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Kevin D BurnsDivision of Nephrology, Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Manish M SoodOttawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Ontario, Canada.
Ann BugejaDivision of Nephrology, Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.ORCID 0000-0002-4106-0451
University of Ottawa · CAOttawa Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have reported agreement between computed tomography (CT) and renography for the determination of split kidney function. However, their correlation with post-donation kidney function remains unclear. We compared CT measurements with renography in assessment of split kidney function (SKF) and their correlations with post-donation kidney function.

methodsA single-centre, retrospective cohort study of 248 donors from January 1, 2009-July 31, 2019 were assessed. Pearson correlations were used to assess post-donation kidney function with renography and CT-based measurements. Furthermore, we examined high risk groups with SKF difference greater than 10% on renography and donors with post-donation eGFR less than 60 mL/min/1.73m2.

results62% of donors were women with a mean (standard deviation) pre-donation eGFR 99 (20) and post-donation eGFR 67 (22) mL/min/1.73m2 at 31 months of follow-up. Post-donation kidney function was poorly correlated with both CT-based measurements and renography, including the subgroup of donors with post-donation eGFR less than 60 mL/min/1.73m2 (r less than 0.4 for all). There was agreement between CT-based measurements and renography for SKF determination (Bland-Altman agreement [bias, 95% limits of agreement] for renography vs: CT volume, 0.76%, -7.60-9.15%; modified ellipsoid,1.01%, -8.38-10.42%; CC dimension, 0.44%, -7.06-7.94); however, CT missed SKF greater than 10% found by renography in 20 out 26 (77%) of donors.

conclusionsIn a single centre study of 248 living donors, we found no correlation between CT or renography and post-donation eGFR. Further research is needed to determine optimal ways to predict remaining kidney function after donation.

Indexed as

Kidney TransplantationAdultFemaleFollow-Up StudiesGlomerular Filtration RateHumansKidneyKidney Function TestsLiving DonorsMaleMiddle AgedNephrectomyPostoperative PeriodRadioisotope RenographyRetrospective StudiesTissue and Organ Harvesting

Identifiers

PMID34214103
PMCPMC8253423
OpenAlexW3176026238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.