Evidence map›Paper›PMID 34214049›Full record

ArticleAging2021

Association between Alzheimer's disease genes and trajectories of cognitive function decline in Han Chinese in Taiwan.

Tsung-Jen Hsieh, Wei-Ju Lee, Yi-Chu Liao, Chih-Cheng Hsu, Yao-Hwei Fang, Tzu-Yu Chen, Yung-Shuan Lin, I-Shou Chang, Shuu-Jiun Wang, Chao A Hsiung and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Endophenotypic effects of theFrontiers in aging neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Tsung-Jen HsiehInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Wei-Ju LeeNeurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.
Yi-Chu LiaoFaculty of Medicine, National Yang-Ming University Schools of Medicine, Taipei, Taiwan.
Chih-Cheng HsuInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Yao-Hwei FangInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Tzu-Yu ChenInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Yung-Shuan LinFaculty of Medicine, National Yang-Ming University Schools of Medicine, Taipei, Taiwan.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Shuu-Jiun WangFaculty of Medicine, National Yang-Ming University Schools of Medicine, Taipei, Taiwan.
Chao A HsiungInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Jong-Ling FuhFaculty of Medicine, National Yang-Ming University Schools of Medicine, Taipei, Taiwan.
Alzheimer’s Disease Neuroimaging Initiative
National Yang Ming Chiao Tung University · TWNational Health Research Institutes · TW

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Genetic background has been considered one of the important contributors to the rate of cognitive decline among patients with Alzheimer's disease (AD). We conducted a 4-year longitudinal follow-up study, recruited 255 AD and 44 mild cognitive impairment (MCI) patients, and used a data-driven trajectory analysis to examine the influence of selected AD risk genes on the age for and the rate of cognitive decline in Han Chinese population. Genotyping of selected single-nucleotide polymorphisms in the

Indexed as

AgedAged, 80 and overAlzheimer DiseaseApolipoproteins EAsian PeopleCognitive DysfunctionFemaleFollow-Up StudiesGenotypeHumansLDL-Receptor Related ProteinsLongitudinal StudiesMaleMembrane Transport ProteinsMental Status and Dementia TestsPolymorphism, Single NucleotideApolipoproteins ELDL-Receptor Related ProteinsMembrane Transport ProteinsSORL1 protein, humanABCA7 geneAlzheimer's diseaseAPOE ɛ4 alleleSORL1 genetrajectory analysis

Identifiers

PMID34214049
PMCPMC8312434
OpenAlexW3177362377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.