ArticleeLife2021
Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Virus Research Special Issue "Cross-kingdom infection by viruses".Virus research · 2026Article
- Interactions between extracellular vesicles and viruses: lessons learned across species and kingdoms.FEMS microbiology reviews · 2026Review
- Review
- Extracellular Vesicles in Arthropods: Biogenesis, Functions, Isolation Methods and Applications.Journal of extracellular vesicles · 2025Review
- Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus.Journal of extracellular vesicles · 2025Article
- Phloem sap from melon plants contains extracellular vesicles that carry active proteasomes which increase in response to aphid infestation.Journal of extracellular vesicles · 2024Article
- Leafhopper salivary carboxylesterase suppresses JA-Ile synthesis to facilitate initial arbovirus transmission in rice phloem.Plant communications · 2024Article
- Plant viruses exploit insect salivary GAPDH to modulate plant defenses.Nature communications · 2024Article
- RAB5A in triple-negative breast cancer: a critical role in macrophage reshaping in an exosomal miR-21-dependent manner.Endocrine-related cancer · 2024Article
- Leafhopper salivary vitellogenin mediates virus transmission to plant phloem.Nature communications · 2024Article
- Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study.Pediatric research · 2023Article
- Advances in the Therapeutic Applications of Plant-Derived Exosomes in the Treatment of Inflammatory Diseases.Biomedicines · 2023Review
- GAPDH mediates plant reovirus-induced incomplete autophagy for persistent viral infection in leafhopper vector.Autophagy · 2023Article
- Exosomal transmission of viruses, a two-edged biological sword.Cell communication and signaling : CCS · 2023Review
- Interaction between the flagellum ofFrontiers in microbiology · 2023Article
- Key role of exportin 6 in exosome-mediated viral transmission from insect vectors to plants.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A nonstructural protein encoded by a rice reovirus induces an incomplete autophagy to promote viral spread in insect vectors.PLoS pathogens · 2022Article
- Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem.eLife · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Numerous piercing-sucking insects can horizontally transmit viral pathogens together with saliva to plant phloem, but the mechanism remains elusive. Here, we report that an important rice reovirus has hijacked small vesicles, referred to as exosomes, to traverse the apical plasmalemma into saliva-stored cavities in the salivary glands of leafhopper vectors. Thus, virions were horizontally transmitted with exosomes into rice phloem to establish the initial plant infection during vector feeding. The purified exosomes secreted from cultured leafhopper cells were enriched with virions. Silencing the exosomal secretion-related small GTPase Rab27a or treatment with the exosomal biogenesis inhibitor GW4869 strongly prevented viral exosomal release in vivo and in vitro. Furthermore, the specific interaction of the 15-nm-long domain of the viral outer capsid protein with Rab5 induced the packaging of virions in exosomes, ultimately activating the Rab27a-dependent exosomal release pathway. We thus anticipate that exosome-mediated viral horizontal transmission is the conserved strategy hijacked by vector-borne viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.