Evidence map›Paper›PMID 34213884›Full record

ArticleACS chemical neuroscience2021

Nicotinic Acetylcholine Receptor Partial Antagonist Polyamides from Tunicates and Their Predatory Sea Slugs.

Noemi D Paguigan, Jortan O Tun, Lee S Leavitt, Zhenjian Lin, Kevin Chase, Cheryl Dowell, Cassandra E Deering-Rice, Albebson L Lim, Manju Karthikeyan, Ronald W Hughen and 8 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Noemi D PaguiganDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Jortan O TunSchool of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
Lee S LeavittSchool of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
Zhenjian LinDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Kevin ChaseSchool of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
Cheryl DowellSchool of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
Cassandra E Deering-RiceDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0002-2103-1194
Albebson L LimDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Manju KarthikeyanSchool of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
Ronald W HughenDepartment of Anesthesiology, School of Medicine, University of Utah, Salt Lake City, Utah 84112, United States.
Jie ZhangDepartment of Anesthesiology, School of Medicine, University of Utah, Salt Lake City, Utah 84112, United States.
Randall T PetersonDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0003-0727-3469
Christopher A ReillyDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0002-5006-1982
Alan R LightDepartment of Anesthesiology, School of Medicine, University of Utah, Salt Lake City, Utah 84112, United States.
Shrinivasan RaghuramanSchool of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
J Michael McIntoshDepartment of Psychiatry, and School of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
Baldomero M OliveraSchool of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
Eric W SchmidtDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0001-5839-694X
University of Utah · US

Funding

Symbiosis and Chemical Diversity GenerationR35GM122521 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2017 to 2021
$2.9M
Development and Application of Nicotinic Acetylcholine Receptor Targeted Peptides for Biomedical ResearchR35GM136430 · NIGMS · UNIVERSITY OF UTAH · PI MCINTOSH, J MICHAEL · 2020 to 2024
$2.3M
NIGMS NIH HHS R35 GM122521NIGMS NIH HHS R35 GM136430
6 · The paper itself

Abstract

In our efforts to discover new drugs to treat pain, we identified molleamines A-E (

Indexed as

Receptors, NicotinicUrochordataalpha7 Nicotinic Acetylcholine ReceptorAnimalsAplysiaMiceNicotinic AntagonistsNylonsRatsalpha7 Nicotinic Acetylcholine ReceptorNicotinic AntagonistsNylonsReceptors, Nicotinicmolleaminemollecarbamatemolleureanicotinic acetylcholine receptorsPolyamide

Identifiers

PMID34213884
PMCPMC8487611
OpenAlexW3177127049

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.