Evidence map›Paper›PMID 34213740›Full record

ArticleJournal of ultrasound2022

Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study.

Kristoffer Grundtvig Skaarup, Mats Christian Højbjerg Lassen, Caroline Espersen, Jannie Nørgaard Lind, Niklas Dyrby Johansen, Morten Sengeløv, Alia Saed Alhakak, Anne Bjerg Nielsen, Kirstine Ravnkilde, Raphael Hauser and 27 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ultrasound, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04377035 (The ECHOVID-19 Study - A Prospective Cohort Study Investigating the Acute Effect of COVID-19 on the Heart and Lung by Ultrasound), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04377035 completednot on this map

The ECHOVID-19 Study - A Prospective Cohort Study Investigating the Acute Effect of COVID-19 on the Heart and Lung by Ultrasound

TypeobservationalSponsorUniversity Hospital, Gentofte, CopenhagenRan2020 to 2021Enrolled305ConditionsCOVID-19
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Predictors of B-line count in hospitalized patients with COVID-19.Frontiers in cardiovascular medicine · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 4 institutions in 2 countries.

Kristoffer Grundtvig Skaarup *Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Mats Christian Højbjerg Lassen *Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.ORCID http://orcid.org/0000-0002-2255-582X
Caroline EspersenCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Jannie Nørgaard LindCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Niklas Dyrby JohansenCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Morten SengeløvCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Alia Saed AlhakakCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Anne Bjerg NielsenCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Kirstine RavnkildeCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Raphael HauserCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Liv Borum SchöpsCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Eva HoltCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Henning BundgaardDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Hellerup, Denmark.
Christian HassagerDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Hellerup, Denmark.
Reza JabbariDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Hellerup, Denmark.
Jørn CarlsenDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Hellerup, Denmark.
Ole KirkDepartment of Infectious Diseases, Rigshospitalet, University of Copenhagen, Hellerup, Denmark.
Uffe BodtgerDepartment of Respiratory and Internal Medicine, Næstved-Slagelse Hospital, University of Southern Denmark, Odense, Denmark.
Matias Greve LindholmDepartment of Cardiology, Zealand University Hospital Roskilde, University of Copenhagen, Hellerup, Denmark.
Lothar WieseDepartment of Infectious Diseases; Zealand University Hospital Roskilde, University of Copenhagen, Hellerup, Denmark.
Ole Peter KristiansenDepartment of Cardiology, Bispebjerg & Frederiksberg Hospital, University of Copenhagen, Hellerup, Denmark.
Emil Schwarz WalstedDepartment of Respiratory Medicine, Bispebjerg & Frederiksberg Hospital, University of Copenhagen, Hellerup, Denmark.
Olav Wendelboe NielsenDepartment of Cardiology, Bispebjerg & Frederiksberg Hospital, University of Copenhagen, Hellerup, Denmark.
Birgitte LindegaardDepartment of Respiratory Medicine and Infectious Diseases, Nordsjællands Hospital, University of Copenhagen, Hellerup, Denmark.
Niels TønderDepartment of Cardiology, Nordsjællands Hospital, University of Copenhagen, Hellerup, Denmark.
Klaus Nielsen JeschkeDepartment of Respiratory Medicine, Amager Hvidovre Hospital, University of Copenhagen, Hellerup, Denmark.
Charlotte Suppli UlrikDepartment of Respiratory Medicine, Amager Hvidovre Hospital, University of Copenhagen, Hellerup, Denmark.
Morten LambertsCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Pradeesh SivapalanDepartment of Medicine, Herlev & Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Jannik PallisgaardCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Gunnar GislasonCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Kasper IversenCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Jens Ulrik Stæhr JensenDepartment of Medicine, Herlev & Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Morten SchouCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark.
Søren Helbo SkaarupDepartment of Respiratory Medicine and Allergy, Aarhus University Hospital, University of Aarhus, Aarhus, Denmark.
Elke PlatzCardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Tor Biering-SørensenCardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, 2900, Hellerup, Denmark. tor.biering-soerensen@regionh.dk.
University of Copenhagen · DKAarhus University Hospital · DKBrigham and Women's Hospital · USUniversity of Southern Denmark · DK

Funding

Improving Pulmonary Congestion Assessment in Heart Failure with Preserved Ejection FractionR01HL148439 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PLATZ, ELKE · 2020 to 2024
$2.1M
NHLBI NIH HHS R01 HL148439Novo Nordisk Fonden NFF20SA0062835
6 · The paper itself

Abstract

purposeSeveral studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE).

methodsA total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores).

resultsMedian time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses.

conclusionIn hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. CLINICALTRIALS: GOV ID: NCT04377035.

Indexed as

COVID-19Venous ThromboembolismAdultAgedFemaleHumansLungMaleProspective StudiesUltrasonographyB-linesCOVID-19Lung ultrasoundVenous thromboembolic events

Identifiers

PMID34213740
PMCPMC8249836
OpenAlexW3174983577

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.