Evidence map›Paper›PMID 34213729›Full record

ReviewCurrent heart failure reports2021

Guideline-Directed Medical Therapy in Females with Heart Failure with Reduced Ejection Fraction.

Anubha Agarwal, Sanne A E Peters, Chanchal Chandramouli, Carolyn S P Lam, Gemma A Figtree, Clare Arnott

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current heart failure reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Anubha AgarwalDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. anubha.agarwal@northwestern.edu.ORCID http://orcid.org/0000-0002-7090-5601
Sanne A E PetersGeorge Institute for Global Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Chanchal ChandramouliNational Heart Centre Singapore, Singapore, Singapore.
Carolyn S P LamNational Heart Centre Singapore, Singapore, Singapore.
Gemma A FigtreeKolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.
Clare ArnottGeorge Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
National Heart Centre Singapore · SGNational University of Singapore · SGNorthwestern University · USRoyal Prince Alfred Hospital · AUThe George Institute for Global Health · GBThe University of Sydney · AU

Funding

Feinberg School of Medicine Institute of Global Health
6 · The paper itself

Abstract

purpose of reviewThis narrative review synthesizes sex differences in guideline-directed medical therapy (GDMT) use and response among female patients with heart failure with reduced ejection fraction (HFrEF), discusses female representation in HFrEF clinical trials, and outlines future areas of investigation to reduce sex disparities in HFrEF care globally. RECENT

findingsObservational registries suggest sex-specific disparities persist in GDMT rates, and there may be key sex-specific differences in optimal dosing of GDMT in HFrEF patients. Underrepresentation of female patients in HF clinical trials is a key barrier, and sex disparities in HF clinical trial leadership may influence sex-specific knowledge generation of medical management of HFrEF patients. There are important sex-specific differences in GDMT use and response among female HFrEF patients that warrant further study. Increasing female representation in HFrEF clinical trials, diversifying HF trial leadership, and embedding sex-specific approaches in the lifecycle of research from conception to reporting are essential to decreasing sex disparities in clinical care of all HFrEF patients.

Indexed as

Heart FailureVentricular Dysfunction, LeftFemaleHumansMaleRegistriesStroke VolumeGuideline-directed medical therapyHeart failure with reduced ejection fractionSex

Identifiers

PMID34213729
OpenAlexW3176214764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.