Evidence map›Paper›PMID 34213717›Full record

Trial reportResearch on child and adolescent psychopathology2021

Using Parent Target Problem Narratives to Evaluate Outcomes in Children with Autism Spectrum Disorder.

Elisabeth Sheridan, Scott Gillespie, Cynthia R Johnson, Luc Lecavalier, Tristram Smith, Naomi Swiezy, Kylan Turner, Jill Pritchett, Daniel W Mruzek, Andrea N Evans and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Research on child and adolescent psychopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07059364 (Empowering Caregivers to Promote Child Independence and Persistence With Activities), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07059364 narecruitingnot on this mapstarted 2025, after this paper: background citation

Empowering Caregivers to Promote Child Independence and Persistence With Activities

TypeinterventionalSponsorUniversity of NebraskaRan2025 to 2026Enrolled32ConditionsProfound AutismArmsCAST Treatment
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Elisabeth SheridanDrexel University, AJ Drexel Autism Institute, 3020 Market Street, Suite 560, Philadelphia, PA, USA.
Scott GillespieEmory University School of Medicine, Marcus Autism Center, 1920 Briarcliff Road NE, Atlanta, GA, USA.
Cynthia R JohnsonCleveland Clinic, Lerner College of Medicine of Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, USA.
Luc LecavalierPsychology and Psychiatry, The Ohio State University, 305 McCampbell Hall, 1581 Dodd Drive, Columbus, OH, USA.
Tristram SmithUniversity of Rochester Medical Center, 601 Elmwood Ave, Box 671, Rochester, NY, USA.
Naomi SwiezyDepartment of Psychiatry, Riley Hospital for Children, PC 1021D PSYC, Indianapolis, IN, USA.
Kylan TurnerSimmons University, 300 The Fenway: W303N, Boston, MA, USA.
Jill PritchettPsychology and Psychiatry, The Ohio State University, 305 McCampbell Hall, 1581 Dodd Drive, Columbus, OH, USA.
Daniel W MruzekUniversity of Rochester Medical Center, 601 Elmwood Ave, Box 671, Rochester, NY, USA.
Andrea N EvansEmory University School of Medicine, Marcus Autism Center, 1920 Briarcliff Road NE, Atlanta, GA, USA.
Karen BearssDepartment of Psychiatry and Behavioral Sciences, Seattle Children's Autism Center, University of Washington, 4909 25th Ave NE, Seattle, WA, USA.
Lawrence ScahillEmory University School of Medicine, Marcus Autism Center, 1920 Briarcliff Road NE, Atlanta, GA, USA. lawrence.scahill@emory.edu.ORCID 0000-0001-5073-1707
Emory University · USThe Ohio State University · USUniversity of Rochester Medical Center · USCleveland Clinic Lerner College of Medicine · USDrexel University · USRiley Hospital for Children · USSimmons University · USUniversity of Washington · US

Funding

1/5-Randomized Trial of Parent Training for Young Children with AutismR01MH081148 · NIMH · YALE UNIVERSITY · PI SCAHILL, LAWRENCE D. · 2010 to 2014
$1.8M
3/5-Randomized Trial of Parent Training for Young Children with AutismR01MH080906 · NIMH · UNIVERSITY OF ROCHESTER · PI SMITH, TRISTRAM H · 2010 to 2014
$1.2M
5/5-Randomized Trial of Parent Training for Young Children with AutismR01MH080965 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHNSON, CYNTHIA R · 2010 to 2014
$1.2M
4/5-Randomized Trial of Parent Training for Young Children with AutismR01MH081221 · NIMH · INDIANA UNIVERSITY INDIANAPOLIS · PI SWIEZY, NAOMI BETH · 2010 to 2014
$1.2M
2/5-Randomized Trial of Parent Training for Young Children with AutismR01MH081105 · NIMH · OHIO STATE UNIVERSITY · PI LECAVALIER, LUC · 2010 to 2014
$1.1M
NIMH NIH HHS R01 MH080906NIMH NIH HHS R01 MH080965NIMH NIH HHS R01 MH081105NIMH NIH HHS R01 MH081148NIMH NIH HHS R01 MH081221
6 · The paper itself

Abstract

This paper examines the reliability and validity of parent target problems (PTPs) in a multi-site randomized controlled trial of parent training (PT) versus psychoeducation (PEP) in children (150 boys, 19 girls; mean age 4.7 ± 1.2 years) with autism spectrum disorder (ASD) and disruptive behavior. At baseline, treatment blind, independent evaluators asked parents to nominate the child's top two problems. Each problem was documented in a brief narrative. Narratives were reviewed and revised at follow-up visits during the six-month trial. When the trial was completed, five judges, blind to treatment condition, independently rated change from baseline on a 9-point scale (1 = normal; 2 = markedly improved; 3 = definitely improved; 4 = equivocally improved; 5 = no change; 6 = possibly worse; 7 = definitely worse; 8 = markedly worse; 9 = disastrously worse) at Weeks 8, 12, 16, and 24 (inter-rater intraclass correlation = 0.78). PTP scores for the two target problems were averaged across the five raters, yielding a mean score for each child at each time point. Mean PTP scores showed improvement in both treatment groups over the 24-week study. Compared to PEP, PTP ratings showed a steeper decline in PT based on significant interaction of group and time (t(df) = 2.14(155.9), p = 0.034; Week 24 effect size = 0.75). In categorical analysis, we compared cutoffs mean PTP scores of 3.0 (definitely improved), 3.25, and 3.5 with the positive response rate on the Clinical Global Impressions-Improvement scale from the original study. Sensitivities ranged from 52-78%. PTP narratives offer a systematic, reliable, and valid way to track child-specific outcomes in clinical trials and clinical practice.

Indexed as

Autism Spectrum DisorderProblem BehaviorChild, PreschoolFemaleHumansMaleNarrationParentsReproducibility of ResultsAutism spectrum disorderDisruptive behaviorsParent trainingTreatment

Identifiers

PMID34213717
OpenAlexW3176942330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.