Evidence map›Paper›PMID 34213713›Full record

ArticleInternational urology and nephrology2022

Could urinary kidney injury molecule-1 be a good marker in subclinical acute kidney injury in mild to moderate COVID-19 infection?

Emre Yasar, Hasan Selcuk Ozger, Hacı Hasan Yeter, Cigdem Yildirim, Zakir Osmanov, Taha Enes Cetin, Omer Faruk Akcay, Neslihan Bukan, Ulver Derici

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Article in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Emre YasarDepartment of Nephrology, Dialysis and Transplantation, Faculty of Medicine, Gazi University, Bahriye Ucok, 06560, Ankara, Turkey. rasayerm@hotmail.com.
Hasan Selcuk OzgerDepartment of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Hacı Hasan YeterDepartment of Nephrology, Dialysis and Transplantation, Faculty of Medicine, Gazi University, Bahriye Ucok, 06560, Ankara, Turkey.
Cigdem YildirimDepartment of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Zakir OsmanovDepartment of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.
Taha Enes CetinDepartment of Internal Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey.
Omer Faruk AkcayDepartment of Nephrology, Dialysis and Transplantation, Faculty of Medicine, Gazi University, Bahriye Ucok, 06560, Ankara, Turkey.
Neslihan BukanDepartment of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ulver DericiDepartment of Nephrology, Dialysis and Transplantation, Faculty of Medicine, Gazi University, Bahriye Ucok, 06560, Ankara, Turkey.
Gazi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate urinary kidney injury molecule-1 (uKIM-1), which is a proximal tubule injury biomarker in subclinical acute kidney injury (AKI) that may occur in COVID-19 infection.

methodsThe study included proteinuric (n = 30) and non-proteinuric (n = 30) patients diagnosed with mild/moderate COVID-19 infection between March and September 2020 and healthy individuals as a control group (n = 20). The uKIM-1, serum creatinine, cystatin C, spot urine protein, creatinine, and albumin levels of the patients were evaluated again after an average of 21 days.

resultsThe median (interquartile range) uKIM-1 level at the time of presentation was 246 (141-347) pg/mL in the proteinuric group, 83 (29-217) pg/mL in the non-proteinuric group, and 55 (21-123) pg/mL in the control group and significantly high in the proteinuric group than the others (p < 0.001). Creatinine and cystatin C were significantly higher in the proteinuric group than in the group without proteinuria, but none of the patients met the KDIGO-AKI criteria. uKIM-1 had a positive correlation with PCR, non-albumin proteinuria, creatinine, cystatin C, CRP, fibrinogen, LDH, and ferritin, and a negative correlation with eGFR and albumin (p < 0.05). In the multivariate regression analysis, non-albumin proteinuria (p = 0.048) and BUN (p = 0.034) were identified as independent factors predicting a high uKIM-1 level. After 21 ± 4 days, proteinuria regressed to normal levels in 20 (67%) patients in the proteinuric group. In addition, the uKIM-1 level, albuminuria, non-albumin proteinuria, and CRP significantly decreased.

conclusionsOur findings support that the kidney is one of the target organs of the COVID-19 and it may cause proximal tubule injury even in patients that do not present with AKI or critical/severe COVID-19 infection.

Indexed as

Acute Kidney InjuryBiomarkersCOVID-19Noncommunicable DiseasesUrinalysisComorbidityCorrelation of DataCreatinineCystatin CFemaleHepatitis A Virus Cellular Receptor 1HumansMaleMiddle AgedProteinuriaReproducibility of ResultsBiomarkersCreatinineCystatin CHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1Acute kidney injuryCOVID-19Non-albuminuric proteinuriaSub-clinicalUrinary kidney injury molecule-1

Identifiers

PMID34213713
PMCPMC8252694
OpenAlexW3175737288

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.