ArticleAnnals of intensive care2021
Long-term quality of life in necrotizing soft-tissue infection survivors: a monocentric prospective cohort study.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05116956 (SKin and Soft Tissue Necrotizing INfections in the Intensive Care Unit), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SKin and Soft Tissue Necrotizing INfections in the Intensive Care Unit: a Prospective Multi-national Cohort Study
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Post-operative quality of life in patients with necrotizing fasciitis: a report from a ten year institutional cohort.International orthopaedics · 2026Article
- Factors associated with in-hospital mortality in necrotising soft tissue infections. a multicentre retrospective cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Antibiotic therapy in necrotizing soft tissue infections: a narrative review of the greater Paris SURFAST consortium.Critical care (London, England) · 2025Review
- Core outcome set for research in necrotising soft tissue infection patients: an international, multidisciplinary, modified Delphi consensus study.Diving and hyperbaric medicine · 2025Article
- Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles.Critical care (London, England) · 2025Review
- Article
- [Necrotizing soft tissue infections].Die Anaesthesiologie · 2024Review
- The impact of necrotizing soft tissue infections on the lives of survivors: a qualitative study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Risk Factors for Predicting Mortality and Amputation of Patients with Necrotizing Soft-Tissue Infections: Retrospective Analysis of 111 Cases from a Single Medical Center.Emergency medicine international · 2023Article
- Impact of severe necrotizing fasciitis on quality of life in the Netherlands.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges.Annals of intensive care · 2022Review
- Antibiotics in Necrotizing Soft Tissue Infections.Antibiotics (Basel, Switzerland) · 2021Review
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCompared to other life-threatening infection survivors, long-term health-related quality of life (QOL) of patients surviving necrotizing soft-tissue infections (NSTI) and its determinants are little known. In this monocentric prospective cohort including NSTI survivors admitted between 2014 and 2017, QOL was assessed during a phone interview using the 36-Item Short-Form Health Survey (SF-36), the Hospital Anxiety and Depression (HAD), the activity of daily living (ADL), instrumental ADL (IADL) scales and the Impact of Event Scale-Revised (IES-R). The primary outcome measure was the SF-36 physical component summary (PCS). NSTI patients were compared according to intensive care unit (ICU) admission status. ICU survivors were matched on SAPS II with non-NSTI related septic shock survivors.
resultsForty-nine NSTI survivors were phone-interviewed and included in the study. Median PCS was decreased compared to the reference population [- 0.97 (- 2.27; - 0.08) SD]. Previous cardiac disease was the only variable associated with PCS alteration [multivariate regression coefficient: - 8.86 (- 17.64; - 0.07), p = 0.048]. Of NSTI survivors, 15.2% had a HAD-D score ≥ 5 and 61.2% an IES-R score ≥ 33. ICU admission was not associated with lower PCS [35.21 (25.49-46.54) versus (vs) 41.82 (24.12-51.01), p = 0.516], but with higher IES-R score [14 (7.5-34) vs 7 (3-18), p = 0.035] and a higher proportion of HAD-D score ≥ 5 (28.6 vs 4.0%, p = 0.036). Compared to non-NSTI septic shock-matched controls, NSTI patients had similar PCS [33.81 (24.58; - 44.39) vs 44.87 (26.71; - 56.01), p = 0.706] but higher HAD-D [3.5 (1-7) vs 3 (1.5-6), p = 0.048] and IES-R scores [18 (8-35) vs 8 (3-19), p = 0.049].
conclusionsLong-term QOL in NSTI survivors is severely impaired, similarly to that of non-NSTI septic shock patients for physical compartments, but with more frequent depressive and/or post-traumatic stress disorders. Only ICU admission and previous cardiac disease were predictive of QOL impairment.
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