Evidence map›Paper›PMID 34213672›Full record

Trial reportClinical rheumatology2021

Genicular nerve block in rheumatoid arthritis: a randomized clinical trial.

A M Elsaman, A Maaty, A Hamed

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06065878 nacompletednot on this mapstarted 2022, after this paper: background citation

Comparison Of The Analgesic Efficacy Of IPACK (Interspace Between The Popliteal Artery And Capsule Of The Posterior Knee) Block Alone And IPACK Block Combined With Genicular Block In Patients Planned For Total Knee Arthroplasty

TypeinterventionalSponsorCenk GacemerRan2022 to 2023Enrolled40ConditionsPain, Joint, Knee Arthropathy, Anesthesia, Orthopedic DisorderArmsIPACK + Genicular Nerve Block
NCT06619080 nacompletednot on this mapstarted 2023, after this paper: background citation

Ecoguided Genicular Nerve Block in Patients With Knee Osteoarthritis by Local Anesthetic or by Combination of Local Anesthetic and Corticoid: Placebo-Controlled Randomized Blind Clinical Trial

TypeinterventionalSponsorHospital Universitario Fundación AlcorcónRan2023 to 2024Enrolled102ConditionsOsteoarthritis, Knee/RehabilitationArmsGenicular nerve block with bupivacaine and corticosteroids, Genicular nerve block with bupivacaine, Genicular nerve block with saline
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

A M ElsamanDepartment of Rheumatology and Rehabilitation, Sohag University Hospital, Sohag, Egypt. ahmed_elsaman@med.sohag.edu.eg.ORCID http://orcid.org/0000-0001-5759-2009
A MaatyDepartment of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
A HamedDepartment of Rheumatology and Rehabilitation, Minia University Hospital, Minia, Egypt.
Minia University Hospital · EGSohag University · EGSuez Canal University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study highlights the effect of a genicular nerve block (GNB) on pain, function, and inflammation outcome measures in rheumatoid arthritis (RA) knees.

methodsA total of sixty-four patients diagnosed with RA using ACR/EULAR 2010 criteria with unilateral persistent knee arthritis were recruited to the study. They were randomly assigned into two groups: group 1 received GNB and group 2 received intra-articular triamcinolone. Both groups were examined by the SOLAR scoring system, visual analog scale (VAS), and Lysholm score at 0, 2, and 12 weeks. A semi-quantitative score was used to assess the tenderness and swelling at the same intervals.

resultsFunction and inflammation improved significantly in group 2 at a 2-week interval as compared to group 1, whereas pain improved in both groups with non-significant differences. After 12 weeks, group 1 showed significant improvement as compared with group 2 for the three outcome measures. Neither the disease activity nor the current medication was related to the GNB effect. Disease duration was negatively related to GNB-induced improvement.

conclusionGNB is a new promising local therapy for RA to control pain, improve function, and alleviate inflammation of the knee joint. Although it has a relatively short-term effect, yet it has outperformed the steroid effect. Key Points • Knee monoarthritis treatment in rheumatoid arthritis is always challenging • GNB has been approved for the treatment of pain in knee osteoarthritis • GNB in this study was able to control active knee arthritis and this effect persisted longer thane intra-articular steroid injection.

Indexed as

Arthritis, RheumatoidNerve BlockOsteoarthritis, KneeHumansInjections, Intra-ArticularKnee JointTreatment OutcomeKnee jointNerve blockRheumatoid arthritis

Identifiers

PMID34213672
OpenAlexW3176674678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.