Evidence map›Paper›PMID 34213642›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

The prevalence, associated factors, clinical impact, and state of diagnosis of delirium in palliative care patients.

Watanachai Klankluang, Sasima Tongsai, Chairat Sriphirom, Arunotai Siriussawakul, Pratamaporn Chanthong, Supakarn Tayjasanant

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Watanachai KlankluangSiriraj Palliative Care Center, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Rd. Bangkoknoi, Bangkok, 10700, Thailand.
Sasima TongsaiOffice for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Chairat SriphiromSiriraj Palliative Care Center, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Rd. Bangkoknoi, Bangkok, 10700, Thailand.
Arunotai SiriussawakulDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pratamaporn ChanthongSiriraj Palliative Care Center, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Rd. Bangkoknoi, Bangkok, 10700, Thailand.
Supakarn TayjasanantSiriraj Palliative Care Center, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Rd. Bangkoknoi, Bangkok, 10700, Thailand. supakarn.tay@mahidol.ac.th.ORCID http://orcid.org/0000-0001-5320-6457
Siriraj Hospital · TH

Funding

Faculty of Medicine Siriraj Hospital, Mahidol University [IO] R016035032
6 · The paper itself

Abstract

purposeThe aim of this study is to establish the prevalence, associated factors, and clinical impact of delirium in newly referred palliative care patients and the percentage of delirium diagnoses missed by primary medical teams.

methodsNewly referred palliative care patients were evaluated and were reviewed for possible associated factors of delirium. Univariable and multivariable analysis were used to identify associated factors. Median overall survival and survival curves were analyzed. The percentage of missed diagnosis in IPD patients was identified.

resultsWe included 350 palliative care patients. Nearly all patients had cancer diagnosis (96.6%). The overall prevalence of delirium was 44.0%. The independent associated factors of delirium were age ≥ 63 years (adjusted odds ratio [aOR], 7.0; 95% CI, 2.2-22.9), palliative performance scale ≤ 20% (aOR, 54.5; 95% CI, 13.1-228.0), brain metastasis (aOR, 15.6; 95% CI, 3.7-66.7), urinary tract infection (aOR, 18.8; 95% CI, 4.7-75.5), sepsis (aOR, 59.0; 95% CI, 4.4-797.8), hyponatremia (aOR, 8.8; 95% CI, 2.6-29.8), and hypercalcemia (not applicable). Interestingly, opioids and benzodiazepines were not associated with delirium. Delirious patients had significantly shorter survival (median survival 11 days). Delirium diagnoses were missed for 76.1%.

conclusionNearly half of the palliative care patients had delirium, which was associated with noticeably short survivals. We identified the independent factors associated with the delirium. Despite having a remarkably high prevalence rate and being a well-known poor prognostic factor, there was still a very high rate of missed delirium diagnoses. Effective, routine, delirium screening of palliative care patients needs to be emphasized.

Indexed as

DeliriumHospice and Palliative Care NursingHumansMiddle AgedPalliative CarePrevalenceReferral and ConsultationAssociated factorCancerDeliriumPrevalenceSupportive careSurvival

Identifiers

PMID34213642
PMCPMC8550445
OpenAlexW3173342003

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.