Evidence map›Paper›PMID 34213599›Full record

ArticleInternational urogynecology journal2021

Perioperative outcomes following pelvic floor reconstruction in women with hereditary disorders of connective tissue: a retrospective cohort study.

Emily R W Davidson, Pakeeza A Alam, Jenifer N Byrnes, Katarzyna Bochenska, Maria Florian-Rodriguez, Charelle M Carter-Brooks, Emily N B Myer, Eshetu A Tefera, Meadow M Good, Robert E Gutman

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International urogynecology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Cases - Ehlers-Danlos syndromes: Review on the urologic implications.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Emily R W DavidsonCleveland Clinic, Cleveland, OH, USA. edavidson@mcw.edu.ORCID http://orcid.org/0000-0003-2842-748X
Pakeeza A AlamMedStar Washington Hospital Center/Georgetown University, Washington, DC, USA.
Jenifer N ByrnesMayo Clinic, Rochester, MN, USA.
Katarzyna BochenskaNorthwestern University, Chicago, IL, USA.
Maria Florian-RodriguezUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Charelle M Carter-BrooksUniversity of Pittsburgh Medical Center/Magee Womens Hospital, Pittsburgh, PA, USA.
Emily N B MyerGreater Baltimore Medical Center, Baltimore, MD, USA.
Eshetu A TeferaMedStar Washington Hospital Center/Georgetown University, Washington, DC, USA.
Meadow M GoodUniversity of Florida College of Medicine Jacksonville, Jacksonville, FL, USA.
Robert E GutmanMedStar Washington Hospital Center/Georgetown University, Washington, DC, USA.
MedStar Washington Hospital Center · USCleveland Clinic · USGreater Baltimore Medical Center · USMagee-Womens Hospital · USMayo Clinic in Arizona · USNorthwestern University · USThe University of Texas Southwestern Medical Center · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisWomen with hereditary disorders of connective tissue (HDCT) are at increased risk of pelvic organ prolapse (POP) and stress urinary incontinence (SUI). We hypothesized that patients would have increased incidence and severity of perioperative complications up to 6 weeks after surgeries for POP/SUI. Secondary objectives were to compare pre- and post-operative pelvic floor symptoms and anatomical support as well as pelvic floor disorder recurrence.

methodsIn this multi-center retrospective cohort study, we identified patients with HDCTs by patient history and ICD-9 codes over an 11-year period. Controls without HDCTs were matched 2:1 to the primary POP or SUI procedure and surgeon. Demographic characteristics, perioperative pelvic floor information and complications were collected. A sample size of 65 HDCT patients and 130 controls was calculated to detect a 20% difference in complications with 80% power and alpha of 0.05.

resultsWe identified 59 HDCT patients and 118 controls. Of the women with HDCTs, 49% had Ehlers-Danlos, 22% joint hypermobility syndrome, 15% Marfan syndrome, and 14% had others. Compared with controls, HDCT patients had more total perioperative complications (46% vs 22%, p = 0.002); an age-adjusted relative risk of complications was 1.4 (CI 0.7-2.6). HDCT patients had more Clavien-Dindo grades I and II complications (p = 0.02, 0.03) and more hospital readmissions (14% vs 3%, p = 0.01) than controls. There was no difference in the incidence of specific complications nor was there a difference in recurrence of POP (10%) or SUI (11%) between groups.

conclusionsPatients with HDCTs had more Clavien-Dindo grade I and II complications following pelvic floor reconstructive surgery and more readmissions.

Indexed as

Pelvic Floor DisordersPelvic Organ ProlapsePlastic Surgery ProceduresUrinary Incontinence, StressFemaleHumansPelvic FloorRetrospective StudiesConnective tissue disorderPelvic floor disordersPelvic organ prolapsePerioperative complicationsStress urinary incontinence

Identifiers

PMID34213599
OpenAlexW3176118687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.