Evidence map›Paper›PMID 34213589›Full record

ArticlePediatric surgery international2021

Clinical presentation and management of childhood intussusception in South Africa.

Sharon Cox, Aletha Withers, Marion Arnold, Milind Chitnis, Corné de Vos, Mari Kirsten, Susanna M le Grange, Jerome Loveland, Sello Machaea, Ashwini Maharaj and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in Pediatric surgery international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06365333 (Pneumatic Reduction For Intussusception In Children), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06365333 completednot on this map

Pneumatic Reduction For Intussusception In Children: A Retrospective Cohort Study In An Ultrahigh Volume Center

TypeobservationalSponsorNational Children's Hospital, VietnamRan2016 to 2024Enrolled3,562ConditionsIntussusceptionArmsFluoroscopic-guided air-enema reduction (FGAR)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sharon CoxDivision of Paediatric Surgery, Red Cross War Memorial Children's Hospital, University of Cape Town, 6th Floor ICH Building, Klipfontein Road, Rondebosch, Cape Town, 7700, South Africa. Sharon.cox@uct.ac.za.ORCID http://orcid.org/0000-0002-3175-8741
Aletha WithersDepartment of Paediatric Surgery, University of the Witwatersrand, Johannesburg, South Africa.
Marion ArnoldDivision of Paediatric Surgery, Red Cross War Memorial Children's Hospital, University of Cape Town, 6th Floor ICH Building, Klipfontein Road, Rondebosch, Cape Town, 7700, South Africa.
Milind ChitnisEast London Hospital Complex, Walter Sisulu University, East London, South Africa.
Corné de VosTygerberg Hospital, University of Stellenbosch, Cape Town, South Africa.
Mari KirstenSteve Biko Academic Hospital/Kalafong Hospital, University of Pretoria, Pretoria, South Africa.
Susanna M le GrangeUniversitas Hospital, University of the Free State, Bloemfontein, South Africa.
Jerome LovelandDepartment of Paediatric Surgery, University of the Witwatersrand, Johannesburg, South Africa.
Sello MachaeaEast London Hospital Complex, Walter Sisulu University, East London, South Africa.
Ashwini MaharajInkosi Albert Luthuli Hospital, University of Kwa-Zulu Natal, Durban, South Africa.
Shabir A MadhiSouth African Medical Research Council: Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Jacqueline E TateCenters for Disease Control and Prevention, Atlanta, GA, USA.
Umesh D ParasharCenters for Disease Control and Prevention, Atlanta, GA, USA.
Michelle J GroomeSouth African Medical Research Council: Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Funding

Rotavirus vaccination in South Africa: safety and factors influencing the immune response to oral enteric vaccine K43TW010382 · FIC · WITS HEALTH CONSORTIUM (PTY), LTD · PI GROOME, MICHELLE JENNIFER · 2016 to 2019
$414k
Bill and Melinda Gates Foundation OPP1066762FIC NIH HHS K43 TW010382FIC NIH HHS K43TW010382
6 · The paper itself

Abstract

purposeWe assessed management and outcomes for intussusception at nine academic hospitals in South Africa.

methodsPatients ≤ 3 years presenting with intussusception between September 2013 and December 2017 were prospectively enrolled at all sites. Additionally, patients presenting between July 2012 and August 2013 were retrospectively enrolled at one site. Demographics, clinical information, diagnostic modality, reduction methods, surgical intervention and outcomes were reviewed.

resultsFour hundred seventy-six patients were enrolled, [54% males, median age 6.5 months (IQR 2.6-32.6)]. Vomiting (92%), bloody stool (91%), abdominal mass (57%), fever (32%) and a rectal mass (29%) represented advanced disease: median symptom duration was 3 days (IQR 1-4). Initial reduction attempts included pneumatic reduction (66%) and upfront surgery (32%). The overall non-surgical reduction rate was 28% and enema perforation rate was 4%. Surgery occurred in 334 (70%), 68 (20%) patients had perforated bowel, bowel resection was required in 61%. Complications included recurrence (2%) and nosocomial sepsis (4%). Length of stay (LOS) was significantly longer in patients who developed complications. Six patients died-a mortality rate of 1%. There was a significant difference in reduction rates, upfront surgery, bowel resection, LOS and mortality between centres with shorter symptom duration compared longer symptom duration.

conclusionDelayed presentation was common and associated with low success for enema reduction, higher operative rates, higher rates of bowel resection and increased LOS. Improved primary health-care worker education and streamlining referral pathways might facilitate timely management.

Indexed as

Intestinal PerforationIntussusceptionChildEnemaFemaleHumansInfantMaleRetrospective StudiesSouth AfricaIntussusceptionOutcomesPaediatricReduction methodsSurgical intervention

Identifiers

PMID34213589
PMCPMC8408053

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.