Evidence map›Paper›PMID 34213090›Full record

ReviewThe journal of pathology. Clinical research2021

More than just acral melanoma: the controversies of defining the disease.

Sara S Bernardes, Ingrid Ferreira, David E Elder, Aretha B Nobre, Héctor Martínez-Said, David J Adams, Carla Daniela Robles-Espinoza, Patricia A Possik

Open access · goldAbstract readReview
In one paragraph

Review in The journal of pathology. Clinical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Poor efficacy of anti PD-1 antibody based immunotherapy in patients with acral melanoma: results from the Spanish Melanoma Group (GEM) registry.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  3. Review
  4. Article
  5. Assessment of the Influence of UVR in Cutaneous Melanoma.Photodermatology, photoimmunology & photomedicine · 2025
    Review
  6. Article
  7. [Characteristics of melanoma in Mexicans seen at "La Raza" National Medical Center].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 5 countries.

Sara S BernardesProgram of Immunology and Tumour Biology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.ORCID 0000-0001-6700-2447
Ingrid FerreiraExperimental Cancer Genetics, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-4321-5250
David E ElderDivision of Anatomic Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4575-2364
Aretha B NobreDivision of Pathology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.ORCID 0000-0002-7177-9838
Héctor Martínez-SaidServicio de Piel y Partes Blandas, Instituto Nacional de Cancerología, Ciudad de México, Mexico.ORCID 0000-0002-9881-4592
David J AdamsExperimental Cancer Genetics, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-9490-0306
Carla Daniela Robles-EspinozaExperimental Cancer Genetics, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0003-3277-7466
Patricia A PossikProgram of Immunology and Tumour Biology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.ORCID 0000-0003-2899-0969
Autonomous University of Queretaro · MXHospital of the University of Pennsylvania · USInstituto Nacional de Câncer - INCA · BRInstituto Nacional de Cancerología · MXUniversidade Federal de Minas Gerais · BRUniversidade Federal do Rio de Janeiro · BRUniversité Libre de Bruxelles · BEWellcome Sanger Institute · GB

Funding

Cancer Research UKMedical Research Council MR/S01473X/1Medical Research Council MR/V000292/1Wellcome Trust
6 · The paper itself

Abstract

Acral melanoma (AM) is a malignant cutaneous melanocytic tumour specifically located on the palms, soles, and nail apparatus, which are areas of glabrous (hairless) skin. Acral lentiginous melanoma, a subtype of AM, represents a histopathological subtype diagnosis of cutaneous melanoma with unique morphological and structural features. Despite clear definitions, the misuse of these terms and the inconsistency in reporting the histopathological features of AM cases have become a major obstacle to the study of the disease. In this review, we discuss the epidemiology, histopathological features, prognosis, and genetic profile of AM, highlighting the differences observed when histopathological subtypes are considered. The increasing global effort to characterise AM cases from ethnically diverse populations would benefit greatly from a more consistent classification of the disease.

Indexed as

MelanomaSkin NeoplasmsAnimalsBiomarkers, TumorFootHandHumansNailsPrognosisBiomarkers, Tumoracral melanomaepidemiologygeneticshistopathologyprognosis

Identifiers

PMID34213090
PMCPMC8503895
OpenAlexW3176113088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.